Home Metabolism Serine hydrolase inhibitor AA26-9 For research use only.

AA26-9

AA26-9 is a potent and broad spectrum inhibitor of Serine hydrolases (SHs).

AA26-9 Chemical Structure

AA26-9 Chemical Structure

CAS: 1312782-34-5

Purity & Quality Control

Batch: S028601 DMSO] 33 mg/mL] false] Water] 33 mg/mL] false] Ethanol] 33 mg/mL] false Purity: 99.77%
99.77

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Choose Selective Serine hydrolase Inhibitors

Biological Activity

Description AA26-9 is a potent and broad spectrum inhibitor of Serine hydrolases (SHs).
Targets
SHs [1]
In vitro
In vitro

A broadspectrum 1,2,3-triazole urea, AA26-9, inhibits about one-third of the more than 40 serine hydrolases found in T cells could be efficiently converted into compounds that potently and selectively inactivate individual serine hydrolases.[1]
Cell Research Cell lines BW5147-derived mouse T-cell hybridoma cells
Concentrations 20 μM
Incubation Time 4 h
Method

Cells were cultured with 20 μM inhibitor for 4 h, lysed, separated into soluble and membrane proteomic fractions and analyzed by competitive gel-based ABPP.

Chemical lnformation & Solubility

Molecular Weight 166.18 Formula

C7H10N4O
CAS No. 1312782-34-5 SDF --
Smiles C1CCN(C1)C(=O)N2C=CN=N2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 33 mg/mL ( (198.57 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 33 mg/mL

Ethanol : 33 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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