Home Microbiology HIV inhibitor ABX464 For research use only.

ABX464

Synonyms: SPL-464

ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.

ABX464 Chemical Structure

ABX464 Chemical Structure

CAS: 1258453-75-6

Purity & Quality Control

Batch: S007601 DMSO] 68 mg/mL] false] Ethanol] 68 mg/mL] false] Water] Insoluble] false Purity: 99.98%
99.98

Related compound libraries

Choose Selective HIV Inhibitors

Biological Activity

Description ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
Targets
HIV-1 [1]
(Cell-free assay)		 HIV-1 [1]
(Cell-free assay)
0.1 μM 0.5 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05177835 Active not recruiting Ulcerative Colitis Abivax S.A. December 3 2021 Phase 2
NCT05121714 Completed Healthy Abivax S.A. December 17 2020 Phase 1
NCT03905109 Unknown status Crohn Disease Abivax S.A. April 15 2020 Phase 2
NCT04023396 Unknown status Ulcerative Colitis Abivax S.A. January 13 2020 Phase 2
NCT04049448 Completed Rheumatoid Arthritis Abivax S.A. October 24 2019 Phase 2

Chemical lnformation & Solubility

Molecular Weight 338.71 Formula

C16H10ClF3N2O
CAS No. 1258453-75-6 SDF --
Smiles C1=CC2=C(C(=C1)Cl)N=C(C=C2)NC3=CC=C(C=C3)OC(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 68 mg/mL ( (200.76 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 68 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy ABX464 | ABX464 supplier | purchase ABX464 | ABX464 cost | ABX464 manufacturer | order ABX464 | ABX464 distributor