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Ademetionine

Synonyms: AdoMet, S-Adenosylmethionine, SAMe

Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.

Ademetionine Chemical Structure

Ademetionine Chemical Structure

CAS: 29908-03-0

Selleck's Ademetionine has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.64%
99.64

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Biological Activity

Description Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
In vitro
In vitro Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA[1].
In Vivo
In vivo SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently (12.5, 25, 50, 100 and 200 mg/kg sc.) decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors, and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05312372 Withdrawn Esophageal Squamous Cell Carcinoma Institut de Recherches Internationales Servier|ADIR a Servier Group company|Servier May 2025 Phase 1|Phase 2
NCT02703610 Withdrawn Pain Albany Medical College July 1 2024 Phase 4
NCT04961957 Not yet recruiting Ankle Fractures|Foot Fracture|Ankle Sprains|Foot Sprain|Toe-walking|Tendonitis of Foot|Apophysitis; Juvenile West Virginia University June 2024 Not Applicable
NCT06188702 Not yet recruiting MTAP-deleted Solid Tumors Servier Bio-Innovation LLC|Institut de Recherches Internationales Servier|Servier March 2024 Phase 1
NCT06147778 Not yet recruiting Cystic Fibrosis Ad scientiam|Vertex Pharmaceuticals Incorporated March 2024 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 398.44 Formula

C15H22N6O5S
CAS No. 29908-03-0 SDF Download Ademetionine SDF
Smiles C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
Storage (From the date of receipt) 3 years -20°C powder (seal)

In vitro
Batch:

DMSO : 80 mg/mL ( (200.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 80 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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