Home Neuronal Signaling AChR inhibitor Adiphenine HCl For research use only.

Adiphenine HCl

Synonyms: NSC 129224

Adiphenine HCl(NSC 129224) is a nicotinic receptor inhibitor, used as an antispasmodic drug.

Adiphenine HCl Chemical Structure

Adiphenine HCl Chemical Structure

CAS: 50-42-0

Purity & Quality Control

Batch: S208201 Water] 70 mg/mL] false] DMSO] 30 mg/mL] false] Ethanol] 18 mg/mL] false Purity: 99.83%
99.83

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Biological Activity

Description Adiphenine HCl(NSC 129224) is a nicotinic receptor inhibitor, used as an antispasmodic drug.
Targets
α3β4 nAChR [1]
(Cell-free assay)		 α1 nAChR [1]
(Cell-free assay)		 α4β2 nAChR [1]
(Cell-free assay)		 α4β4 nAChR [1]
(Cell-free assay)
1.8 μM 1.9 μM 3.7 μM 6.3 μM

Chemical lnformation & Solubility

Molecular Weight 347.88 Formula

C20H25NO2.HCl
CAS No. 50-42-0 SDF Download Adiphenine HCl SDF
Smiles CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 70 mg/mL

DMSO : 30 mg/mL ( (86.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 18 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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