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Afatinib Dimaleate

Name: Afatinib Dimaleate
Brand: Selleck Chemicals
SKU: S7810
Rating: 5 (168 reviews)

Synonyms: BIBW2992 Dimaleate

Catalog No.S7810 Purity: 99.98%

Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.

Afatinib Dimaleate Chemical Structure

CAS: 850140-73-7

Selleck's Afatinib Dimaleate has been cited by 168 publications

Purity & Quality Control

Batch: Purity: 99.98%

99.98

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Cell Data

Cell Lines	Assay Type	Incubation Time	Activity Description	PMID
HCC827 cell	Proliferation assay		Antiproliferative activity against human HCC827 cells after 96 hrs by MTS assay, IC50=8 nM	20550212
NCI-H1563	Growth inhibition assay		Inhibition of human NCI-H1563 cell growth in a cell viability assay. IC50=9.76031 μM	SANGER
NCI-H1573	Growth inhibition assay		Inhibition of human NCI-H1573 cell growth in a cell viability assay. IC50=0.7363 μM	SANGER
NCI-H1581	Growth inhibition assay		Inhibition of human NCI-H1581 cell growth in a cell viability assay. IC50=29.3145 μM	SANGER
NCI-H1648	Growth inhibition assay		Inhibition of human NCI-H1648 cell growth in a cell viability assay. IC50=0.44182 μM	SANGER
NCI-H1793	Growth inhibition assay		Inhibition of human NCI-H1793 cell growth in a cell viability assay. IC50=14.2087 μM	SANGER
NCI-H1838	Growth inhibition assay		Inhibition of human NCI-H1838 cell growth in a cell viability assay. IC50=0.60299 μM	SANGER
NCI-H1770	Growth inhibition assay		Inhibition of human NCI-H1770 cell growth in a cell viability assay. IC50=0.1028 μM	SANGER
NCI-H1651	Growth inhibition assay		Inhibition of human NCI-H1651 cell growth in a cell viability assay. IC50=25.597 μM	SANGER
NCI-H1975	Growth inhibition assay		Inhibition of human NCI-H1975 cell growth in a cell viability assay. IC50=0.61728 μM	SANGER
NCI-H1666	Growth inhibition assay		Inhibition of human NCI-H1666 cell growth in a cell viability assay. IC50=1.80948 μM	SANGER
NCI-H2009	Growth inhibition assay		Inhibition of human NCI-H2009 cell growth in a cell viability assay. IC50=3.61216 μM	SANGER
NCI-H2126	Growth inhibition assay		Inhibition of human NCI-H2126 cell growth in a cell viability assay. IC50=0.51926 μM	SANGER
NCI-H1693	Growth inhibition assay		Inhibition of human NCI-H1693 cell growth in a cell viability assay. IC50=3.84181 μM	SANGER
NCI-H2087	Growth inhibition assay		Inhibition of human NCI-H2087 cell growth in a cell viability assay. IC50=49.9682 μM	SANGER
NCI-H2029	Growth inhibition assay		Inhibition of human NCI-H2029 cell growth in a cell viability assay. IC50=43.5581 μM	SANGER
NCI-H2170	Growth inhibition assay		Inhibition of human NCI-H2170 cell growth in a cell viability assay. IC50=0.03728 μM	SANGER
NCI-H226	Growth inhibition assay		Inhibition of human NCI-H226 cell growth in a cell viability assay. IC50=49.7785 μM	SANGER
NCI-H2030	Growth inhibition assay		Inhibition of human NCI-H2030 cell growth in a cell viability assay. IC50=14.6448 μM	SANGER
NCI-H2052	Growth inhibition assay		Inhibition of human NCI-H2052 cell growth in a cell viability assay. IC50=21.8963 μM	SANGER
NCI-H292	Growth inhibition assay		Inhibition of human NCI-H292 cell growth in a cell viability assay. IC50=0.0609 μM	SANGER
NCI-H441	Growth inhibition assay		Inhibition of human NCI-H441 cell growth in a cell viability assay. IC50=3.59841 μM	SANGER
NCI-H2291	Growth inhibition assay		Inhibition of human NCI-H2291 cell growth in a cell viability assay. IC50=5.98943 μM	SANGER
NCI-H358	Growth inhibition assay		Inhibition of human NCI-H358 cell growth in a cell viability assay. IC50=0.5321 μM	SANGER
NCI-H460	Growth inhibition assay		Inhibition of human NCI-H460 cell growth in a cell viability assay. IC50=46.523 μM	SANGER
NCI-H661	Growth inhibition assay		Inhibition of human NCI-H661 cell growth in a cell viability assay. IC50=16.9694 μM	SANGER
NCI-H23	Growth inhibition assay		Inhibition of human NCI-H23 cell growth in a cell viability assay. IC50=37.4196 μM	SANGER
NCI-H630	Growth inhibition assay		Inhibition of human NCI-H630 cell growth in a cell viability assay. IC50=1.45582 μM	SANGER
NCI-H2342	Growth inhibition assay		Inhibition of human NCI-H2342 cell growth in a cell viability assay. IC50=17.557 μM	SANGER
NCI-H69	Growth inhibition assay		Inhibition of human NCI-H69 cell growth in a cell viability assay. IC50=0.21451 μM	SANGER
NCI-H650	Growth inhibition assay		Inhibition of human NCI-H650 cell growth in a cell viability assay. IC50=11.2418 μM	SANGER
NCI-H747	Growth inhibition assay		Inhibition of human NCI-H747 cell growth in a cell viability assay. IC50=5.42472 μM	SANGER
NCI-H2405	Growth inhibition assay		Inhibition of human NCI-H2405 cell growth in a cell viability assay. IC50=17.1974 μM	SANGER
NCI-H520	Growth inhibition assay		Inhibition of human NCI-H520 cell growth in a cell viability assay. IC50=24.8861 μM	SANGER
NCI-H810	Growth inhibition assay		Inhibition of human NCI-H810 cell growth in a cell viability assay. IC50=34.7278 μM	SANGER
NCI-H720	Growth inhibition assay		Inhibition of human NCI-H720 cell growth in a cell viability assay. IC50=0.05325 μM	SANGER
NCI-SNU-1	Growth inhibition assay		Inhibition of human NCI-SNU-1 cell growth in a cell viability assay. IC50=3.69735 μM	SANGER
NH-12	Growth inhibition assay		Inhibition of human NH-12 cell growth in a cell viability assay. IC50=7.72808 μM	SANGER
NCI-SNU-5	Growth inhibition assay		Inhibition of human NCI-SNU-5 cell growth in a cell viability assay. IC50=1.239 μM	SANGER
NKM-1	Growth inhibition assay		Inhibition of human NKM-1 cell growth in a cell viability assay. IC50=3.18744 μM	SANGER
NCI-H526	Growth inhibition assay		Inhibition of human NCI-H526 cell growth in a cell viability assay. IC50=0.07823 μM	SANGER
NTERA-S-cl-D1	Growth inhibition assay		Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. IC50=5.54537 μM	SANGER
NMC-G1	Growth inhibition assay		Inhibition of human NMC-G1 cell growth in a cell viability assay. IC50=12.9234 μM	SANGER
NCI-H82	Growth inhibition assay		Inhibition of human NCI-H82 cell growth in a cell viability assay. IC50=1.54006 μM	SANGER
NCI-H1623	Growth inhibition assay		Inhibition of human NCI-H1623 cell growth in a cell viability assay. IC50=0.08025 μM	SANGER
NOMO-1	Growth inhibition assay		Inhibition of human NOMO-1 cell growth in a cell viability assay. IC50=34.5703 μM	SANGER
NCI-N87	Growth inhibition assay		Inhibition of human NCI-N87 cell growth in a cell viability assay. IC50=0.02773 μM	SANGER
NCI-H1650	Growth inhibition assay		Inhibition of human NCI-H1650 cell growth in a cell viability assay. IC50=9.60946 μM	SANGER
NCI-H1703	Growth inhibition assay		Inhibition of human NCI-H1703 cell growth in a cell viability assay. IC50=9.34375 μM	SANGER
NCI-H1755	Growth inhibition assay		Inhibition of human NCI-H1755 cell growth in a cell viability assay. IC50=41.8725 μM	SANGER
NCI-H1993	Growth inhibition assay		Inhibition of human NCI-H1993 cell growth in a cell viability assay. IC50=8.33631 μM	SANGER
NCI-H209	Growth inhibition assay		Inhibition of human NCI-H209 cell growth in a cell viability assay. IC50=0.2046 μM	SANGER
NCI-H2122	Growth inhibition assay		Inhibition of human NCI-H2122 cell growth in a cell viability assay. IC50=34.3471 μM	SANGER
NY	Growth inhibition assay		Inhibition of human NY cell growth in a cell viability assay. IC50=3.53655 μM	SANGER
OAW-42	Growth inhibition assay		Inhibition of human OAW-42 cell growth in a cell viability assay. IC50=3.50026 μM	SANGER
OC-314	Growth inhibition assay		Inhibition of human OC-314 cell growth in a cell viability assay. IC50=15.4714 μM	SANGER
NCI-H2228	Growth inhibition assay		Inhibition of human NCI-H2228 cell growth in a cell viability assay. IC50=32.6602 μM	SANGER
OCI-AML2	Growth inhibition assay		Inhibition of human OCI-AML2 cell growth in a cell viability assay. IC50=8.95481 μM	SANGER
OCUB-M	Growth inhibition assay		Inhibition of human OCUB-M cell growth in a cell viability assay. IC50=3.76187 μM	SANGER
OE33	Growth inhibition assay		Inhibition of human OE33 cell growth in a cell viability assay. IC50=13.786 μM	SANGER
NCI-H28	Growth inhibition assay		Inhibition of human NCI-H28 cell growth in a cell viability assay. IC50=7.16405 μM	SANGER
OS-RC-2	Growth inhibition assay		Inhibition of human OS-RC-2 cell growth in a cell viability assay. IC50=9.0219 μM	SANGER
ONS-76	Growth inhibition assay		Inhibition of human ONS-76 cell growth in a cell viability assay. IC50=41.4709 μM	SANGER
OVCAR-3	Growth inhibition assay		Inhibition of human OVCAR-3 cell growth in a cell viability assay. IC50=2.67167 μM	SANGER
OVCAR-4	Growth inhibition assay		Inhibition of human OVCAR-4 cell growth in a cell viability assay. IC50=10.8835 μM	SANGER
OVCAR-5	Growth inhibition assay		Inhibition of human OVCAR-5 cell growth in a cell viability assay. IC50=13.1593 μM	SANGER
P12-ICHIKAWA	Growth inhibition assay		Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay. IC50=25.4785 μM	SANGER
NCI-H446	Growth inhibition assay		Inhibition of human NCI-H446 cell growth in a cell viability assay. IC50=37.4862 μM	SANGER
NCI-H510A	Growth inhibition assay		Inhibition of human NCI-H510A cell growth in a cell viability assay. IC50=31.4006 μM	SANGER
NCI-H596	Growth inhibition assay		Inhibition of human NCI-H596 cell growth in a cell viability assay. IC50=12.0369 μM	SANGER
PA-1	Growth inhibition assay		Inhibition of human PA-1 cell growth in a cell viability assay. IC50=49.8335 μM	SANGER
PC-14	Growth inhibition assay		Inhibition of human PC-14 cell growth in a cell viability assay. IC50=0.05668 μM	SANGER
PANC-03-27	Growth inhibition assay		Inhibition of human PANC-03-27 cell growth in a cell viability assay. IC50=2.16631 μM	SANGER
PANC-08-13	Growth inhibition assay		Inhibition of human PANC-08-13 cell growth in a cell viability assay. IC50=1.16416 μM	SANGER
NCI-H727	Growth inhibition assay		Inhibition of human NCI-H727 cell growth in a cell viability assay. IC50=8.1042 μM	SANGER
RD	Growth inhibition assay		Inhibition of human RD cell growth in a cell viability assay. IC50=29.5233 μM	SANGER
QIMR-WIL	Growth inhibition assay		Inhibition of human QIMR-WIL cell growth in a cell viability assay. IC50=16.7105 μM	SANGER
RERF-LC-MS	Growth inhibition assay		Inhibition of human RERF-LC-MS cell growth in a cell viability assay. IC50=17.5508 μM	SANGER
RCC10RGB	Growth inhibition assay		Inhibition of human RCC10RGB cell growth in a cell viability assay. IC50=18.0559 μM	SANGER
RH-18	Growth inhibition assay		Inhibition of human RH-18 cell growth in a cell viability assay. IC50=18.0035 μM	SANGER
RO82-W-1	Growth inhibition assay		Inhibition of human RO82-W-1 cell growth in a cell viability assay. IC50=32.1604 μM	SANGER
RKO	Growth inhibition assay		Inhibition of human RKO cell growth in a cell viability assay. IC50=14.5075 μM	SANGER
RPMI-7951	Growth inhibition assay		Inhibition of human RPMI-7951 cell growth in a cell viability assay. IC50=3.0759 μM	SANGER
NEC8	Growth inhibition assay		Inhibition of human NEC8 cell growth in a cell viability assay. IC50=14.5472 μM	SANGER
RPMI-8226	Growth inhibition assay		Inhibition of human RPMI-8226 cell growth in a cell viability assay. IC50=4.11631 μM	SANGER
RS4-11	Growth inhibition assay		Inhibition of human RS4-11 cell growth in a cell viability assay. IC50=12.1725 μM	SANGER
RXF393	Growth inhibition assay		Inhibition of human RXF393 cell growth in a cell viability assay. IC50=36.3785 μM	SANGER
NOS-1	Growth inhibition assay		Inhibition of human NOS-1 cell growth in a cell viability assay. IC50=11.711 μM	SANGER
Ramos-2G6-4C10	Growth inhibition assay		Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay. IC50=14.0202 μM	SANGER
S-117	Growth inhibition assay		Inhibition of human S-117 cell growth in a cell viability assay. IC50=36.3008 μM	SANGER
SCC-25	Growth inhibition assay		Inhibition of human SCC-25 cell growth in a cell viability assay. IC50=0.84171 μM	SANGER
SBC-1	Growth inhibition assay		Inhibition of human SBC-1 cell growth in a cell viability assay. IC50=0.18959 μM	SANGER
SCC-15	Growth inhibition assay		Inhibition of human SCC-15 cell growth in a cell viability assay. IC50=1.39451 μM	SANGER
SCC-4	Growth inhibition assay		Inhibition of human SCC-4 cell growth in a cell viability assay. IC50=8.44059 μM	SANGER
NUGC-3	Growth inhibition assay		Inhibition of human NUGC-3 cell growth in a cell viability assay. IC50=0.38373 μM	SANGER
SCC-9	Growth inhibition assay		Inhibition of human SCC-9 cell growth in a cell viability assay. IC50=37.7838 μM	SANGER
SCH	Growth inhibition assay		Inhibition of human SCH cell growth in a cell viability assay. IC50=18.6456 μM	SANGER
OAW-28	Growth inhibition assay		Inhibition of human OAW-28 cell growth in a cell viability assay. IC50=7.94578 μM	SANGER
SF126	Growth inhibition assay		Inhibition of human SF126 cell growth in a cell viability assay. IC50=23.6924 μM	SANGER
SF295	Growth inhibition assay		Inhibition of human SF295 cell growth in a cell viability assay. IC50=26.0425 μM	SANGER
OE19	Growth inhibition assay		Inhibition of human OE19 cell growth in a cell viability assay. IC50=1.71512 μM	SANGER
SF539	Growth inhibition assay		Inhibition of human SF539 cell growth in a cell viability assay. IC50=9.23562 μM	SANGER
SH-4	Growth inhibition assay		Inhibition of human SH-4 cell growth in a cell viability assay. IC50=32.1858 μM	SANGER
SHP-77	Growth inhibition assay		Inhibition of human SHP-77 cell growth in a cell viability assay. IC50=29.6182 μM	SANGER
OMC-1	Growth inhibition assay		Inhibition of human OMC-1 cell growth in a cell viability assay. IC50=2.08169 μM	SANGER
SK-HEP-1	Growth inhibition assay		Inhibition of human SK-HEP-1 cell growth in a cell viability assay. IC50=30.6326 μM	SANGER
SJSA-1	Growth inhibition assay		Inhibition of human SJSA-1 cell growth in a cell viability assay. IC50=27.0176 μM	SANGER
OVCAR-8	Growth inhibition assay		Inhibition of human OVCAR-8 cell growth in a cell viability assay. IC50=15.8861 μM	SANGER
SK-LU-1	Growth inhibition assay		Inhibition of human SK-LU-1 cell growth in a cell viability assay. IC50=40.6568 μM	SANGER
SK-MEL-1	Growth inhibition assay		Inhibition of human SK-MEL-1 cell growth in a cell viability assay. IC50=13.7135 μM	SANGER
SK-MEL-24	Growth inhibition assay		Inhibition of human SK-MEL-24 cell growth in a cell viability assay. IC50=11.2366 μM	SANGER
P30-OHK	Growth inhibition assay		Inhibition of human P30-OHK cell growth in a cell viability assay. IC50=35.8752 μM	SANGER
PANC-10-05	Growth inhibition assay		Inhibition of human PANC-10-05 cell growth in a cell viability assay. IC50=14.6247 μM	SANGER
SK-MEL-3	Growth inhibition assay		Inhibition of human SK-MEL-3 cell growth in a cell viability assay. IC50=16.4787 μM	SANGER
SK-MES-1	Growth inhibition assay		Inhibition of human SK-MES-1 cell growth in a cell viability assay. IC50=1.11487 μM	SANGER
PC-3	Growth inhibition assay		Inhibition of human PC-3 cell growth in a cell viability assay. IC50=19.9604 μM	SANGER
SK-NEP-1	Growth inhibition assay		Inhibition of human SK-NEP-1 cell growth in a cell viability assay. IC50=1.17513 μM	SANGER
SK-N-DZ	Growth inhibition assay		Inhibition of human SK-N-DZ cell growth in a cell viability assay. IC50=28.6885 μM	SANGER
SK-OV-3	Growth inhibition assay		Inhibition of human SK-OV-3 cell growth in a cell viability assay. IC50=8.71329 μM	SANGER
PFSK-1	Growth inhibition assay		Inhibition of human PFSK-1 cell growth in a cell viability assay. IC50=13.06 μM	SANGER
SK-PN-DW	Growth inhibition assay		Inhibition of human SK-PN-DW cell growth in a cell viability assay. IC50=35.4369 μM	SANGER
SK-UT-1	Growth inhibition assay		Inhibition of human SK-UT-1 cell growth in a cell viability assay. IC50=13.1083 μM	SANGER
RCM-1	Growth inhibition assay		Inhibition of human RCM-1 cell growth in a cell viability assay. IC50=2.52938 μM	SANGER
SKG-IIIa	Growth inhibition assay		Inhibition of human SKG-IIIa cell growth in a cell viability assay. IC50=3.52237 μM	SANGER
SNU-387	Growth inhibition assay		Inhibition of human SNU-387 cell growth in a cell viability assay. IC50=40.4553 μM	SANGER
SNU-449	Growth inhibition assay		Inhibition of human SNU-449 cell growth in a cell viability assay. IC50=3.65826 μM	SANGER
RMG-I	Growth inhibition assay		Inhibition of human RMG-I cell growth in a cell viability assay. IC50=7.39296 μM	SANGER
SNU-C2B	Growth inhibition assay		Inhibition of human SNU-C2B cell growth in a cell viability assay. IC50=2.68616 μM	SANGER
RPMI-2650	Growth inhibition assay		Inhibition of human RPMI-2650 cell growth in a cell viability assay. IC50=11.5885 μM	SANGER
SW1116	Growth inhibition assay		Inhibition of human SW1116 cell growth in a cell viability assay. IC50=1.01287 μM	SANGER
SW13	Growth inhibition assay		Inhibition of human SW13 cell growth in a cell viability assay. IC50=0.16216 μM	SANGER
SW1463	Growth inhibition assay		Inhibition of human SW1463 cell growth in a cell viability assay. IC50=15.0485 μM	SANGER
RPMI-8866	Growth inhibition assay		Inhibition of human RPMI-8866 cell growth in a cell viability assay. IC50=27.7562 μM	SANGER
RT-112	Growth inhibition assay		Inhibition of human RT-112 cell growth in a cell viability assay. IC50=22.8616 μM	SANGER
SW1710	Growth inhibition assay		Inhibition of human SW1710 cell growth in a cell viability assay. IC50=8.18515 μM	SANGER
RVH-421	Growth inhibition assay		Inhibition of human RVH-421 cell growth in a cell viability assay. IC50=35.7645 μM	SANGER
SW626	Growth inhibition assay		Inhibition of human SW626 cell growth in a cell viability assay. IC50=11.5755 μM	SANGER
SW1990	Growth inhibition assay		Inhibition of human SW1990 cell growth in a cell viability assay. IC50=16.1755 μM	SANGER
SW756	Growth inhibition assay		Inhibition of human SW756 cell growth in a cell viability assay. IC50=6.91176 μM	SANGER
SW48	Growth inhibition assay		Inhibition of human SW48 cell growth in a cell viability assay. IC50=1.25432 μM	SANGER
SW620	Growth inhibition assay		Inhibition of human SW620 cell growth in a cell viability assay. IC50=5.24964 μM	SANGER
SAS	Growth inhibition assay		Inhibition of human SAS cell growth in a cell viability assay. IC50=0.48398 μM	SANGER
SW837	Growth inhibition assay		Inhibition of human SW837 cell growth in a cell viability assay. IC50=12.9028 μM	SANGER
SW872	Growth inhibition assay		Inhibition of human SW872 cell growth in a cell viability assay. IC50=42.6331 μM	SANGER
SW900	Growth inhibition assay		Inhibition of human SW900 cell growth in a cell viability assay. IC50=7.82121 μM	SANGER
SW948	Growth inhibition assay		Inhibition of human SW948 cell growth in a cell viability assay. IC50=46.4462 μM	SANGER
SiHa	Growth inhibition assay		Inhibition of human SiHa cell growth in a cell viability assay. IC50=23.9327 μM	SANGER
SW962	Growth inhibition assay		Inhibition of human SW962 cell growth in a cell viability assay. IC50=5.62032 μM	SANGER
T-24	Growth inhibition assay		Inhibition of human T-24 cell growth in a cell viability assay. IC50=34.0205 μM	SANGER
Saos-2	Growth inhibition assay		Inhibition of human Saos-2 cell growth in a cell viability assay. IC50=19.1162 μM	SANGER
T47D	Growth inhibition assay		Inhibition of human T47D cell growth in a cell viability assay. IC50=3.62217 μM	SANGER
T98G	Growth inhibition assay		Inhibition of human T98G cell growth in a cell viability assay. IC50=27.5846 μM	SANGER
T84	Growth inhibition assay		Inhibition of human T84 cell growth in a cell viability assay. IC50=11.3907 μM	SANGER
SF268	Growth inhibition assay		Inhibition of human SF268 cell growth in a cell viability assay. IC50=29.5932 μM	SANGER
22RV1	Growth inhibition assay		Inhibition of human 22RV1 cell growth in a cell viability assay. IC50=34.1754 μM	SANGER
TE-1	Growth inhibition assay		Inhibition of human TE-1 cell growth in a cell viability assay. IC50=1.81475 μM	SANGER
23132-87	Growth inhibition assay		Inhibition of human 23132-87 cell growth in a cell viability assay. IC50=0.31923 μM	SANGER
SJRH30	Growth inhibition assay		Inhibition of human SJRH30 cell growth in a cell viability assay. IC50=30.2108 μM	SANGER
5637	Growth inhibition assay		Inhibition of human 5637 cell growth in a cell viability assay. IC50=1.0151 μM	SANGER
647-V	Growth inhibition assay		Inhibition of human 647-V cell growth in a cell viability assay. IC50=3.98452 μM	SANGER
639-V	Growth inhibition assay		Inhibition of human 639-V cell growth in a cell viability assay. IC50=31.5243 μM	SANGER
769-P	Growth inhibition assay		Inhibition of human 769-P cell growth in a cell viability assay. IC50=2.29037 μM	SANGER
8-MG-BA	Growth inhibition assay		Inhibition of human 8-MG-BA cell growth in a cell viability assay. IC50=36.9483 μM	SANGER
8305C	Growth inhibition assay		Inhibition of human 8305C cell growth in a cell viability assay. IC50=3.75911 μM	SANGER
SK-MEL-2	Growth inhibition assay		Inhibition of human SK-MEL-2 cell growth in a cell viability assay. IC50=32.6527 μM	SANGER
8505C	Growth inhibition assay		Inhibition of human 8505C cell growth in a cell viability assay. IC50=13.2067 μM	SANGER
A204	Growth inhibition assay		Inhibition of human A204 cell growth in a cell viability assay. IC50=32.5069 μM	SANGER
A101D	Growth inhibition assay		Inhibition of human A101D cell growth in a cell viability assay. IC50=49.9425 μM	SANGER
SK-MEL-28	Growth inhibition assay		Inhibition of human SK-MEL-28 cell growth in a cell viability assay. IC50=19.3363 μM	SANGER
SK-N-AS	Growth inhibition assay		Inhibition of human SK-N-AS cell growth in a cell viability assay. IC50=21.8275 μM	SANGER
A2780	Growth inhibition assay		Inhibition of human A2780 cell growth in a cell viability assay. IC50=2.06294 μM	SANGER
A3-KAW	Growth inhibition assay		Inhibition of human A3-KAW cell growth in a cell viability assay. IC50=23.1003 μM	SANGER
A4-Fuk	Growth inhibition assay		Inhibition of human A4-Fuk cell growth in a cell viability assay. IC50=22.1419 μM	SANGER
A431	Growth inhibition assay		Inhibition of human A431 cell growth in a cell viability assay. IC50=0.48233 μM	SANGER
A388	Growth inhibition assay		Inhibition of human A388 cell growth in a cell viability assay. IC50=0.36857 μM	SANGER
SK-N-FI	Growth inhibition assay		Inhibition of human SK-N-FI cell growth in a cell viability assay. IC50=28.433 μM	SANGER
A549	Growth inhibition assay		Inhibition of human A549 cell growth in a cell viability assay. IC50=6.12553 μM	SANGER
A673	Growth inhibition assay		Inhibition of human A673 cell growth in a cell viability assay. IC50=41.5157 μM	SANGER
ACN	Growth inhibition assay		Inhibition of human ACN cell growth in a cell viability assay. IC50=0.55094 μM	SANGER
A704	Growth inhibition assay		Inhibition of human A704 cell growth in a cell viability assay. IC50=18.4753 μM	SANGER
SN12C	Growth inhibition assay		Inhibition of human SN12C cell growth in a cell viability assay. IC50=2.91964 μM	SANGER
ALL-PO	Growth inhibition assay		Inhibition of human ALL-PO cell growth in a cell viability assay. IC50=11.2512 μM	SANGER
ABC-1	Growth inhibition assay		Inhibition of human ABC-1 cell growth in a cell viability assay. IC50=34.3693 μM	SANGER
ACHN	Growth inhibition assay		Inhibition of human ACHN cell growth in a cell viability assay. IC50=0.31994 μM	SANGER
AN3-CA	Growth inhibition assay		Inhibition of human AN3-CA cell growth in a cell viability assay. IC50=28.4395 μM	SANGER
ATN-1	Growth inhibition assay		Inhibition of human ATN-1 cell growth in a cell viability assay. IC50=33.1416 μM	SANGER
AU565	Growth inhibition assay		Inhibition of human AU565 cell growth in a cell viability assay. IC50=0.08504 μM	SANGER
BALL-1	Growth inhibition assay		Inhibition of human BALL-1 cell growth in a cell viability assay. IC50=9.21907 μM	SANGER
BB65-RCC	Growth inhibition assay		Inhibition of human BB65-RCC cell growth in a cell viability assay. IC50=0.34593 μM	SANGER
BB49-HNC	Growth inhibition assay		Inhibition of human BB49-HNC cell growth in a cell viability assay. IC50=43.2356 μM	SANGER
SW1417	Growth inhibition assay		Inhibition of human SW1417 cell growth in a cell viability assay. IC50=4.12147 μM	SANGER
BHY	Growth inhibition assay		Inhibition of human BHY cell growth in a cell viability assay. IC50=0.28655 μM	SANGER
BCPAP	Growth inhibition assay		Inhibition of human BCPAP cell growth in a cell viability assay. IC50=27.137 μM	SANGER
BFTC-905	Growth inhibition assay		Inhibition of human BFTC-905 cell growth in a cell viability assay. IC50=29.2706 μM	SANGER
BE-13	Growth inhibition assay		Inhibition of human BE-13 cell growth in a cell viability assay. IC50=7.98112 μM	SANGER
BHT-101	Growth inhibition assay		Inhibition of human BHT-101 cell growth in a cell viability assay. IC50=14.241 μM	SANGER
SW1573	Growth inhibition assay		Inhibition of human SW1573 cell growth in a cell viability assay. IC50=11.7294 μM	SANGER
SW684	Growth inhibition assay		Inhibition of human SW684 cell growth in a cell viability assay. IC50=19.1326 μM	SANGER
BPH-1	Growth inhibition assay		Inhibition of human BPH-1 cell growth in a cell viability assay. IC50=0.05988 μM	SANGER
SW780	Growth inhibition assay		Inhibition of human SW780 cell growth in a cell viability assay. IC50=25.3264 μM	SANGER
BT-474	Growth inhibition assay		Inhibition of human BT-474 cell growth in a cell viability assay. IC50=0.04986 μM	SANGER
SW954	Growth inhibition assay		Inhibition of human SW954 cell growth in a cell viability assay. IC50=1.20214 μM	SANGER
C2BBe1	Growth inhibition assay		Inhibition of human C2BBe1 cell growth in a cell viability assay. IC50=14.764 μM	SANGER
BV-173	Growth inhibition assay		Inhibition of human BV-173 cell growth in a cell viability assay. IC50=0.17596 μM	SANGER
SW982	Growth inhibition assay		Inhibition of human SW982 cell growth in a cell viability assay. IC50=18.2671 μM	SANGER
Becker	Growth inhibition assay		Inhibition of human Becker cell growth in a cell viability assay. IC50=20.7201 μM	SANGER
BxPC-3	Growth inhibition assay		Inhibition of human BxPC-3 cell growth in a cell viability assay. IC50=10.0973 μM	SANGER
C8166	Growth inhibition assay		Inhibition of human C8166 cell growth in a cell viability assay. IC50=33.8854 μM	SANGER
C-33-A	Growth inhibition assay		Inhibition of human C-33-A cell growth in a cell viability assay. IC50=0.81297 μM	SANGER
C3A	Growth inhibition assay		Inhibition of human C3A cell growth in a cell viability assay. IC50=30.2927 μM	SANGER
CAKI-1	Growth inhibition assay		Inhibition of human CAKI-1 cell growth in a cell viability assay. IC50=1.78211 μM	SANGER
TCCSUP	Growth inhibition assay		Inhibition of human TCCSUP cell growth in a cell viability assay. IC50=28.6418 μM	SANGER
CAL-120	Growth inhibition assay		Inhibition of human CAL-120 cell growth in a cell viability assay. IC50=15.1447 μM	SANGER
CAL-12T	Growth inhibition assay		Inhibition of human CAL-12T cell growth in a cell viability assay. IC50=1.88945 μM	SANGER
CAL-27	Growth inhibition assay		Inhibition of human CAL-27 cell growth in a cell viability assay. IC50=0.17636 μM	SANGER
CAL-51	Growth inhibition assay		Inhibition of human CAL-51 cell growth in a cell viability assay. IC50=31.5667 μM	SANGER
CAL-39	Growth inhibition assay		Inhibition of human CAL-39 cell growth in a cell viability assay. IC50=0.11792 μM	SANGER
CAL-54	Growth inhibition assay		Inhibition of human CAL-54 cell growth in a cell viability assay. IC50=0.61621 μM	SANGER
697	Growth inhibition assay		Inhibition of human 697 cell growth in a cell viability assay. IC50=28.6331 μM	SANGER
CAL-85-1	Growth inhibition assay		Inhibition of human CAL-85-1 cell growth in a cell viability assay. IC50=9.87383 μM	SANGER
CAL-62	Growth inhibition assay		Inhibition of human CAL-62 cell growth in a cell viability assay. IC50=43.4028 μM	SANGER
CAL-72	Growth inhibition assay		Inhibition of human CAL-72 cell growth in a cell viability assay. IC50=10.9391 μM	SANGER
786-0	Growth inhibition assay		Inhibition of human 786-0 cell growth in a cell viability assay. IC50=3.06408 μM	SANGER
TE-11	Growth inhibition assay		Inhibition of human TE-11 cell growth in a cell viability assay. IC50=26.7752 μM	SANGER
A172	Growth inhibition assay		Inhibition of human A172 cell growth in a cell viability assay. IC50=12.0798 μM	SANGER
TE-5	Growth inhibition assay		Inhibition of human TE-5 cell growth in a cell viability assay. IC50=5.4085 μM	SANGER
TE-6	Growth inhibition assay		Inhibition of human TE-6 cell growth in a cell viability assay. IC50=0.40246 μM	SANGER
TE-9	Growth inhibition assay		Inhibition of human TE-9 cell growth in a cell viability assay. IC50=3.84382 μM	SANGER
TGBC24TKB	Growth inhibition assay		Inhibition of human TGBC24TKB cell growth in a cell viability assay. IC50=1.6823 μM	SANGER
A2058	Growth inhibition assay		Inhibition of human A2058 cell growth in a cell viability assay. IC50=15.0409 μM	SANGER
TI-73	Growth inhibition assay		Inhibition of human TI-73 cell growth in a cell viability assay. IC50=0.14715 μM	SANGER
A427	Growth inhibition assay		Inhibition of human A427 cell growth in a cell viability assay. IC50=37.9107 μM	SANGER
TK10	Growth inhibition assay		Inhibition of human TK10 cell growth in a cell viability assay. IC50=0.26738 μM	SANGER
TGBC1TKB	Growth inhibition assay		Inhibition of human TGBC1TKB cell growth in a cell viability assay. IC50=30.1238 μM	SANGER
A498	Growth inhibition assay		Inhibition of human A498 cell growth in a cell viability assay. IC50=0.40674 μM	SANGER
AGS	Growth inhibition assay		Inhibition of human AGS cell growth in a cell viability assay. IC50=0.83648 μM	SANGER
U-2-OS	Growth inhibition assay		Inhibition of human U-2-OS cell growth in a cell viability assay. IC50=17.5307 μM	SANGER
U-118-MG	Growth inhibition assay		Inhibition of human U-118-MG cell growth in a cell viability assay. IC50=36.8847 μM	SANGER
U-266	Growth inhibition assay		Inhibition of human U-266 cell growth in a cell viability assay. IC50=16.2299 μM	SANGER
U031	Growth inhibition assay		Inhibition of human U031 cell growth in a cell viability assay. IC50=5.25424 μM	SANGER
UACC-257	Growth inhibition assay		Inhibition of human UACC-257 cell growth in a cell viability assay. IC50=41.7369 μM	SANGER
U-87-MG	Growth inhibition assay		Inhibition of human U-87-MG cell growth in a cell viability assay. IC50=4.10481 μM	SANGER
AsPC-1	Growth inhibition assay		Inhibition of human AsPC-1 cell growth in a cell viability assay. IC50=19.6471 μM	SANGER
UACC-893	Growth inhibition assay		Inhibition of human UACC-893 cell growth in a cell viability assay. IC50=0.11885 μM	SANGER
BB30-HNC	Growth inhibition assay		Inhibition of human BB30-HNC cell growth in a cell viability assay. IC50=0.16576 μM	SANGER
UM-UC-3	Growth inhibition assay		Inhibition of human UM-UC-3 cell growth in a cell viability assay. IC50=9.9503 μM	SANGER
VM-CUB-1	Growth inhibition assay		Inhibition of human VM-CUB-1 cell growth in a cell viability assay. IC50=4.86819 μM	SANGER
UMC-11	Growth inhibition assay		Inhibition of human UMC-11 cell growth in a cell viability assay. IC50=26.4514 μM	SANGER
BEN	Growth inhibition assay		Inhibition of human BEN cell growth in a cell viability assay. IC50=27.8517 μM	SANGER
WM-115	Growth inhibition assay		Inhibition of human WM-115 cell growth in a cell viability assay. IC50=11.7588 μM	SANGER
BFTC-909	Growth inhibition assay		Inhibition of human BFTC-909 cell growth in a cell viability assay. IC50=9.06799 μM	SANGER
YAPC	Growth inhibition assay		Inhibition of human YAPC cell growth in a cell viability assay. IC50=11.9259 μM	SANGER
BT-20	Growth inhibition assay		Inhibition of human BT-20 cell growth in a cell viability assay. IC50=3.69795 μM	SANGER
YKG-1	Growth inhibition assay		Inhibition of human YKG-1 cell growth in a cell viability assay. IC50=1.05419 μM	SANGER
CAPAN-1	Growth inhibition assay		Inhibition of human CAPAN-1 cell growth in a cell viability assay. IC50=30.5181 μM	SANGER
no-10	Growth inhibition assay		Inhibition of human no-10 cell growth in a cell viability assay. IC50=16.6343 μM	SANGER
CAMA-1	Growth inhibition assay		Inhibition of human CAMA-1 cell growth in a cell viability assay. IC50=9.28128 μM	SANGER
CAS-1	Growth inhibition assay		Inhibition of human CAS-1 cell growth in a cell viability assay. IC50=46.7701 μM	SANGER
BT-549	Growth inhibition assay		Inhibition of human BT-549 cell growth in a cell viability assay. IC50=6.66889 μM	SANGER
CCRF-CEM	Growth inhibition assay		Inhibition of human CCRF-CEM cell growth in a cell viability assay. IC50=25.967 μM	SANGER
CGTH-W-1	Growth inhibition assay		Inhibition of human CGTH-W-1 cell growth in a cell viability assay. IC50=42.4955 μM	SANGER
CHP-212	Growth inhibition assay		Inhibition of human CHP-212 cell growth in a cell viability assay. IC50=22.3222 μM	SANGER
C32	Growth inhibition assay		Inhibition of human C32 cell growth in a cell viability assay. IC50=9.33064 μM	SANGER
COLO-320-HSR	Growth inhibition assay		Inhibition of human COLO-320-HSR cell growth in a cell viability assay. IC50=18.746 μM	SANGER
CAL-33	Growth inhibition assay		Inhibition of human CAL-33 cell growth in a cell viability assay. IC50=0.20184 μM	SANGER
COLO-678	Growth inhibition assay		Inhibition of human COLO-678 cell growth in a cell viability assay. IC50=0.80834 μM	SANGER
COLO-680N	Growth inhibition assay		Inhibition of human COLO-680N cell growth in a cell viability assay. IC50=44.339 μM	SANGER
COLO-684	Growth inhibition assay		Inhibition of human COLO-684 cell growth in a cell viability assay. IC50=16.9477 μM	SANGER
TE-10	Growth inhibition assay		Inhibition of human TE-10 cell growth in a cell viability assay. IC50=2.68078 μM	SANGER
COLO-741	Growth inhibition assay		Inhibition of human COLO-741 cell growth in a cell viability assay. IC50=20.66 μM	SANGER
COLO-792	Growth inhibition assay		Inhibition of human COLO-792 cell growth in a cell viability assay. IC50=25.2732 μM	SANGER
TE-12	Growth inhibition assay		Inhibition of human TE-12 cell growth in a cell viability assay. IC50=1.80414 μM	SANGER
COR-L23	Growth inhibition assay		Inhibition of human COR-L23 cell growth in a cell viability assay. IC50=24.1767 μM	SANGER
COLO-824	Growth inhibition assay		Inhibition of human COLO-824 cell growth in a cell viability assay. IC50=15.1579 μM	SANGER
COR-L105	Growth inhibition assay		Inhibition of human COR-L105 cell growth in a cell viability assay. IC50=0.21084 μM	SANGER
COR-L88	Growth inhibition assay		Inhibition of human COR-L88 cell growth in a cell viability assay. IC50=0.64113 μM	SANGER
TE-8	Growth inhibition assay		Inhibition of human TE-8 cell growth in a cell viability assay. IC50=1.91377 μM	SANGER
TGBC11TKB	Growth inhibition assay		Inhibition of human TGBC11TKB cell growth in a cell viability assay. IC50=47.1777 μM	SANGER
CP50-MEL-B	Growth inhibition assay		Inhibition of human CP50-MEL-B cell growth in a cell viability assay. IC50=17.0343 μM	SANGER
CP66-MEL	Growth inhibition assay		Inhibition of human CP66-MEL cell growth in a cell viability assay. IC50=15.4688 μM	SANGER
CTB-1	Growth inhibition assay		Inhibition of human CTB-1 cell growth in a cell viability assay. IC50=4.8488 μM	SANGER
CaR-1	Growth inhibition assay		Inhibition of human CaR-1 cell growth in a cell viability assay. IC50=2.28281 μM	SANGER
CTV-1	Growth inhibition assay		Inhibition of human CTV-1 cell growth in a cell viability assay. IC50=0.64392 μM	SANGER
CW-2	Growth inhibition assay		Inhibition of human CW-2 cell growth in a cell viability assay. IC50=0.46914 μM	SANGER
Ca-Ski	Growth inhibition assay		Inhibition of human Ca-Ski cell growth in a cell viability assay. IC50=7.64259 μM	SANGER
U251	Growth inhibition assay		Inhibition of human U251 cell growth in a cell viability assay. IC50=40.4054 μM	SANGER
Ca9-22	Growth inhibition assay		Inhibition of human Ca9-22 cell growth in a cell viability assay. IC50=0.08353 μM	SANGER
Calu-3	Growth inhibition assay		Inhibition of human Calu-3 cell growth in a cell viability assay. IC50=0.81434 μM	SANGER
Capan-2	Growth inhibition assay		Inhibition of human Capan-2 cell growth in a cell viability assay. IC50=3.46875 μM	SANGER
UACC-62	Growth inhibition assay		Inhibition of human UACC-62 cell growth in a cell viability assay. IC50=11.2368 μM	SANGER
ChaGo-K-1	Growth inhibition assay		Inhibition of human ChaGo-K-1 cell growth in a cell viability assay. IC50=32.007 μM	SANGER
VA-ES-BJ	Growth inhibition assay		Inhibition of human VA-ES-BJ cell growth in a cell viability assay. IC50=35.4648 μM	SANGER
D-263MG	Growth inhibition assay		Inhibition of human D-263MG cell growth in a cell viability assay. IC50=33.8378 μM	SANGER
VMRC-RCZ	Growth inhibition assay		Inhibition of human VMRC-RCZ cell growth in a cell viability assay. IC50=8.01697 μM	SANGER
D-336MG	Growth inhibition assay		Inhibition of human D-336MG cell growth in a cell viability assay. IC50=30.2892 μM	SANGER
D-392MG	Growth inhibition assay		Inhibition of human D-392MG cell growth in a cell viability assay. IC50=35.0565 μM	SANGER
D-566MG	Growth inhibition assay		Inhibition of human D-566MG cell growth in a cell viability assay. IC50=29.9393 μM	SANGER
D-423MG	Growth inhibition assay		Inhibition of human D-423MG cell growth in a cell viability assay. IC50=5.61705 μM	SANGER
DBTRG-05MG	Growth inhibition assay		Inhibition of human DBTRG-05MG cell growth in a cell viability assay. IC50=13.0633 μM	SANGER
D-502MG	Growth inhibition assay		Inhibition of human D-502MG cell growth in a cell viability assay. IC50=8.29282 μM	SANGER
ZR-75-30	Growth inhibition assay		Inhibition of human ZR-75-30 cell growth in a cell viability assay. IC50=0.09545 μM	SANGER
D-542MG	Growth inhibition assay		Inhibition of human D-542MG cell growth in a cell viability assay. IC50=1.01064 μM	SANGER
DMS-273	Growth inhibition assay		Inhibition of human DMS-273 cell growth in a cell viability assay. IC50=32.5322 μM	SANGER
DJM-1	Growth inhibition assay		Inhibition of human DJM-1 cell growth in a cell viability assay. IC50=6.92012 μM	SANGER
DK-MG	Growth inhibition assay		Inhibition of human DK-MG cell growth in a cell viability assay. IC50=30.5456 μM	SANGER
no-11	Growth inhibition assay		Inhibition of human no-11 cell growth in a cell viability assay. IC50=3.53564 μM	SANGER
DMS-114	Growth inhibition assay		Inhibition of human DMS-114 cell growth in a cell viability assay. IC50=40.8374 μM	SANGER
DMS-79	Growth inhibition assay		Inhibition of human DMS-79 cell growth in a cell viability assay. IC50=40.5889 μM	SANGER
DOK	Growth inhibition assay		Inhibition of human DOK cell growth in a cell viability assay. IC50=0.03194 μM	SANGER
CFPAC-1	Growth inhibition assay		Inhibition of human CFPAC-1 cell growth in a cell viability assay. IC50=1.42493 μM	SANGER
DSH1	Growth inhibition assay		Inhibition of human DSH1 cell growth in a cell viability assay. IC50=0.03314 μM	SANGER
DU-145	Growth inhibition assay		Inhibition of human DU-145 cell growth in a cell viability assay. IC50=0.44833 μM	SANGER
CHL-1	Growth inhibition assay		Inhibition of human CHL-1 cell growth in a cell viability assay. IC50=0.01839 μM	SANGER
DU-4475	Growth inhibition assay		Inhibition of human DU-4475 cell growth in a cell viability assay. IC50=1.40121 μM	SANGER
DoTc2-4510	Growth inhibition assay		Inhibition of human DoTc2-4510 cell growth in a cell viability assay. IC50=0.32219 μM	SANGER
Daoy	Growth inhibition assay		Inhibition of human Daoy cell growth in a cell viability assay. IC50=24.126 μM	SANGER
Detroit562	Growth inhibition assay		Inhibition of human Detroit562 cell growth in a cell viability assay. IC50=1.70152 μM	SANGER
ECC10	Growth inhibition assay		Inhibition of human ECC10 cell growth in a cell viability assay. IC50=1.55369 μM	SANGER
EC-GI-10	Growth inhibition assay		Inhibition of human EC-GI-10 cell growth in a cell viability assay. IC50=0.05912 μM	SANGER
EFM-19	Growth inhibition assay		Inhibition of human EFM-19 cell growth in a cell viability assay. IC50=37.7967 μM	SANGER
COLO-679	Growth inhibition assay		Inhibition of human COLO-679 cell growth in a cell viability assay. IC50=35.388 μM	SANGER
EFO-21	Growth inhibition assay		Inhibition of human EFO-21 cell growth in a cell viability assay. IC50=11.1045 μM	SANGER
EFO-27	Growth inhibition assay		Inhibition of human EFO-27 cell growth in a cell viability assay. IC50=0.05182 μM	SANGER
EKVX	Growth inhibition assay		Inhibition of human EKVX cell growth in a cell viability assay. IC50=1.01064 μM	SANGER
EGI-1	Growth inhibition assay		Inhibition of human EGI-1 cell growth in a cell viability assay. IC50=28.5928 μM	SANGER
EPLC-272H	Growth inhibition assay		Inhibition of human EPLC-272H cell growth in a cell viability assay. IC50=4.41533 μM	SANGER
COLO-800	Growth inhibition assay		Inhibition of human COLO-800 cell growth in a cell viability assay. IC50=7.41446 μM	SANGER
COLO-829	Growth inhibition assay		Inhibition of human COLO-829 cell growth in a cell viability assay. IC50=8.80976 μM	SANGER
ES3	Growth inhibition assay		Inhibition of human ES3 cell growth in a cell viability assay. IC50=16.9134 μM	SANGER
ES8	Growth inhibition assay		Inhibition of human ES8 cell growth in a cell viability assay. IC50=17.6087 μM	SANGER
ES4	Growth inhibition assay		Inhibition of human ES4 cell growth in a cell viability assay. IC50=0.97836 μM	SANGER
ETK-1	Growth inhibition assay		Inhibition of human ETK-1 cell growth in a cell viability assay. IC50=1.37456 μM	SANGER
EW-1	Growth inhibition assay		Inhibition of human EW-1 cell growth in a cell viability assay. IC50=45.9689 μM	SANGER
ES5	Growth inhibition assay		Inhibition of human ES5 cell growth in a cell viability assay. IC50=4.83723 μM	SANGER
EW-11	Growth inhibition assay		Inhibition of human EW-11 cell growth in a cell viability assay. IC50=9.17653 μM	SANGER
EW-13	Growth inhibition assay		Inhibition of human EW-13 cell growth in a cell viability assay. IC50=14.0352 μM	SANGER
EW-18	Growth inhibition assay		Inhibition of human EW-18 cell growth in a cell viability assay. IC50=0.68698 μM	SANGER
EW-3	Growth inhibition assay		Inhibition of human EW-3 cell growth in a cell viability assay. IC50=1.07883 μM	SANGER
EW-24	Growth inhibition assay		Inhibition of human EW-24 cell growth in a cell viability assay. IC50=21.3945 μM	SANGER
Calu-6	Growth inhibition assay		Inhibition of human Calu-6 cell growth in a cell viability assay. IC50=30.2963 μM	SANGER
FTC-133	Growth inhibition assay		Inhibition of human FTC-133 cell growth in a cell viability assay. IC50=11.1407 μM	SANGER
EoL-1-cell	Growth inhibition assay		Inhibition of human EoL-1-cell cell growth in a cell viability assay. IC50=0.26892 μM	SANGER
FADU	Growth inhibition assay		Inhibition of human FADU cell growth in a cell viability assay. IC50=0.54404 μM	SANGER
G-401	Growth inhibition assay		Inhibition of human G-401 cell growth in a cell viability assay. IC50=1.67413 μM	SANGER
GAK	Growth inhibition assay		Inhibition of human GAK cell growth in a cell viability assay. IC50=25.2963 μM	SANGER
GAMG	Growth inhibition assay		Inhibition of human GAMG cell growth in a cell viability assay. IC50=3.91314 μM	SANGER
GMS-10	Growth inhibition assay		Inhibition of human GMS-10 cell growth in a cell viability assay. IC50=2.03517 μM	SANGER
GB-1	Growth inhibition assay		Inhibition of human GB-1 cell growth in a cell viability assay. IC50=25.4068 μM	SANGER
GI-ME-N	Growth inhibition assay		Inhibition of human GI-ME-N cell growth in a cell viability assay. IC50=31.0571 μM	SANGER
GOTO	Growth inhibition assay		Inhibition of human GOTO cell growth in a cell viability assay. IC50=31.8506 μM	SANGER
GCIY	Growth inhibition assay		Inhibition of human GCIY cell growth in a cell viability assay. IC50=1.08104 μM	SANGER
GT3TKB	Growth inhibition assay		Inhibition of human GT3TKB cell growth in a cell viability assay. IC50=8.67964 μM	SANGER
GP5d	Growth inhibition assay		Inhibition of human GP5d cell growth in a cell viability assay. IC50=6.97394 μM	SANGER
D-283MED	Growth inhibition assay		Inhibition of human D-283MED cell growth in a cell viability assay. IC50=18.0088 μM	SANGER
GR-ST	Growth inhibition assay		Inhibition of human GR-ST cell growth in a cell viability assay. IC50=28.6696 μM	SANGER
DB	Growth inhibition assay		Inhibition of human DB cell growth in a cell viability assay. IC50=7.61005 μM	SANGER
HC-1	Growth inhibition assay		Inhibition of human HC-1 cell growth in a cell viability assay. IC50=5.51839 μM	SANGER
HAL-01	Growth inhibition assay		Inhibition of human HAL-01 cell growth in a cell viability assay. IC50=8.5191 μM	SANGER
HCC1187	Growth inhibition assay		Inhibition of human HCC1187 cell growth in a cell viability assay. IC50=20.6734 μM	SANGER
HCC1419	Growth inhibition assay		Inhibition of human HCC1419 cell growth in a cell viability assay. IC50=0.36408 μM	SANGER
HCC1395	Growth inhibition assay		Inhibition of human HCC1395 cell growth in a cell viability assay. IC50=14.9338 μM	SANGER
DEL	Growth inhibition assay		Inhibition of human DEL cell growth in a cell viability assay. IC50=10.3946 μM	SANGER
DOHH-2	Growth inhibition assay		Inhibition of human DOHH-2 cell growth in a cell viability assay. IC50=20.5463 μM	SANGER
HCC1937	Growth inhibition assay		Inhibition of human HCC1937 cell growth in a cell viability assay. IC50=12.7564 μM	SANGER
HCC38	Growth inhibition assay		Inhibition of human HCC38 cell growth in a cell viability assay. IC50=42.9618 μM	SANGER
HCC1954	Growth inhibition assay		Inhibition of human HCC1954 cell growth in a cell viability assay. IC50=11.0754 μM	SANGER
HCC2218	Growth inhibition assay		Inhibition of human HCC2218 cell growth in a cell viability assay. IC50=0.009869 μM	SANGER
HCE-4	Growth inhibition assay		Inhibition of human HCE-4 cell growth in a cell viability assay. IC50=9.21558 μM	SANGER
HCE-T	Growth inhibition assay		Inhibition of human HCE-T cell growth in a cell viability assay. IC50=0.88428 μM	SANGER
HL-60	Growth inhibition assay		Inhibition of human HL-60 cell growth in a cell viability assay. IC50=4.86611 μM	SANGER
HCT-116	Growth inhibition assay		Inhibition of human HCT-116 cell growth in a cell viability assay. IC50=4.41007 μM	SANGER
HEL	Growth inhibition assay		Inhibition of human HEL cell growth in a cell viability assay. IC50=7.71203 μM	SANGER
HCT-15	Growth inhibition assay		Inhibition of human HCT-15 cell growth in a cell viability assay. IC50=22.7441 μM	SANGER
HLE	Growth inhibition assay		Inhibition of human HLE cell growth in a cell viability assay. IC50=0.35046 μM	SANGER
HH	Growth inhibition assay		Inhibition of human HH cell growth in a cell viability assay. IC50=16.5162 μM	SANGER
HD-MY-Z	Growth inhibition assay		Inhibition of human HD-MY-Z cell growth in a cell viability assay. IC50=48.786 μM	SANGER
HO-1-N-1	Growth inhibition assay		Inhibition of human HO-1-N-1 cell growth in a cell viability assay. IC50=0.27853 μM	SANGER
HN	Growth inhibition assay		Inhibition of human HN cell growth in a cell viability assay. IC50=0.13077 μM	SANGER
HDLM-2	Growth inhibition assay		Inhibition of human HDLM-2 cell growth in a cell viability assay. IC50=0.00572 μM	SANGER
EM-2	Growth inhibition assay		Inhibition of human EM-2 cell growth in a cell viability assay. IC50=14.8576 μM	SANGER
HOP-92	Growth inhibition assay		Inhibition of human HOP-92 cell growth in a cell viability assay. IC50=26.1226 μM	SANGER
HPAF-II	Growth inhibition assay		Inhibition of human HPAF-II cell growth in a cell viability assay. IC50=41.6709 μM	SANGER
HSC-2	Growth inhibition assay		Inhibition of human HSC-2 cell growth in a cell viability assay. IC50=0.16837 μM	SANGER
ES1	Growth inhibition assay		Inhibition of human ES1 cell growth in a cell viability assay. IC50=19.9213 μM	SANGER
HSC-3	Growth inhibition assay		Inhibition of human HSC-3 cell growth in a cell viability assay. IC50=0.21198 μM	SANGER
HSC-4	Growth inhibition assay		Inhibition of human HSC-4 cell growth in a cell viability assay. IC50=0.01748 μM	SANGER
ES7	Growth inhibition assay		Inhibition of human ES7 cell growth in a cell viability assay. IC50=19.6292 μM	SANGER
HT-144	Growth inhibition assay		Inhibition of human HT-144 cell growth in a cell viability assay. IC50=27.4032 μM	SANGER
ESS-1	Growth inhibition assay		Inhibition of human ESS-1 cell growth in a cell viability assay. IC50=18.5206 μM	SANGER
HT-29	Growth inhibition assay		Inhibition of human HT-29 cell growth in a cell viability assay. IC50=3.07309 μM	SANGER
HT-3	Growth inhibition assay		Inhibition of human HT-3 cell growth in a cell viability assay. IC50=1.28753 μM	SANGER
HT55	Growth inhibition assay		Inhibition of human HT55 cell growth in a cell viability assay. IC50=2.5738 μM	SANGER
EW-16	Growth inhibition assay		Inhibition of human EW-16 cell growth in a cell viability assay. IC50=27.2947 μM	SANGER
HTC-C3	Growth inhibition assay		Inhibition of human HTC-C3 cell growth in a cell viability assay. IC50=27.2561 μM	SANGER
HT-1376	Growth inhibition assay		Inhibition of human HT-1376 cell growth in a cell viability assay. IC50=1.01513 μM	SANGER
EW-22	Growth inhibition assay		Inhibition of human EW-22 cell growth in a cell viability assay. IC50=41.8697 μM	SANGER
Hs-578-T	Growth inhibition assay		Inhibition of human Hs-578-T cell growth in a cell viability assay. IC50=45.0294 μM	SANGER
G-361	Growth inhibition assay		Inhibition of human G-361 cell growth in a cell viability assay. IC50=26.1027 μM	SANGER
HuH-7	Growth inhibition assay		Inhibition of human HuH-7 cell growth in a cell viability assay. IC50=28.4028 μM	SANGER
HuO-3N1	Growth inhibition assay		Inhibition of human HuO-3N1 cell growth in a cell viability assay. IC50=5.24043 μM	SANGER
HuO9	Growth inhibition assay		Inhibition of human HuO9 cell growth in a cell viability assay. IC50=11.8774 μM	SANGER
G-402	Growth inhibition assay		Inhibition of human G-402 cell growth in a cell viability assay. IC50=35.9867 μM	SANGER
IGROV-1	Growth inhibition assay		Inhibition of human IGROV-1 cell growth in a cell viability assay. IC50=0.25952 μM	SANGER
HuP-T3	Growth inhibition assay		Inhibition of human HuP-T3 cell growth in a cell viability assay. IC50=16.6576 μM	SANGER
HuP-T4	Growth inhibition assay		Inhibition of human HuP-T4 cell growth in a cell viability assay. IC50=0.6976 μM	SANGER
GCT	Growth inhibition assay		Inhibition of human GCT cell growth in a cell viability assay. IC50=20.3026 μM	SANGER
IST-MEL1	Growth inhibition assay		Inhibition of human IST-MEL1 cell growth in a cell viability assay. IC50=11.456 μM	SANGER
GI-1	Growth inhibition assay		Inhibition of human GI-1 cell growth in a cell viability assay. IC50=22.7658 μM	SANGER
IST-MES1	Growth inhibition assay		Inhibition of human IST-MES1 cell growth in a cell viability assay. IC50=18.4428 μM	SANGER
J82	Growth inhibition assay		Inhibition of human J82 cell growth in a cell viability assay. IC50=15.057 μM	SANGER
JAR	Growth inhibition assay		Inhibition of human JAR cell growth in a cell viability assay. IC50=19.299 μM	SANGER
H-EMC-SS	Growth inhibition assay		Inhibition of human H-EMC-SS cell growth in a cell viability assay. IC50=32.9678 μM	SANGER
JEG-3	Growth inhibition assay		Inhibition of human JEG-3 cell growth in a cell viability assay. IC50=22.378 μM	SANGER
JVM-2	Growth inhibition assay		Inhibition of human JVM-2 cell growth in a cell viability assay. IC50=0.88299 μM	SANGER
H9	Growth inhibition assay		Inhibition of human H9 cell growth in a cell viability assay. IC50=0.07132 μM	SANGER
KARPAS-299	Growth inhibition assay		Inhibition of human KARPAS-299 cell growth in a cell viability assay. IC50=20.3422 μM	SANGER
JVM-3	Growth inhibition assay		Inhibition of human JVM-3 cell growth in a cell viability assay. IC50=7.89599 μM	SANGER
KALS-1	Growth inhibition assay		Inhibition of human KALS-1 cell growth in a cell viability assay. IC50=23.1414 μM	SANGER
HCC1569	Growth inhibition assay		Inhibition of human HCC1569 cell growth in a cell viability assay. IC50=2.58297 μM	SANGER
KARPAS-45	Growth inhibition assay		Inhibition of human KARPAS-45 cell growth in a cell viability assay. IC50=0.01671 μM	SANGER
KE-37	Growth inhibition assay		Inhibition of human KE-37 cell growth in a cell viability assay. IC50=25.7315 μM	SANGER
KASUMI-1	Growth inhibition assay		Inhibition of human KASUMI-1 cell growth in a cell viability assay. IC50=0.00911 μM	SANGER
KGN	Growth inhibition assay		Inhibition of human KGN cell growth in a cell viability assay. IC50=32.633 μM	SANGER
KLE	Growth inhibition assay		Inhibition of human KLE cell growth in a cell viability assay. IC50=4.40819 μM	SANGER
HCC1806	Growth inhibition assay		Inhibition of human HCC1806 cell growth in a cell viability assay. IC50=0.69666 μM	SANGER
KM-H2	Growth inhibition assay		Inhibition of human KM-H2 cell growth in a cell viability assay. IC50=34.1779 μM	SANGER
KM12	Growth inhibition assay		Inhibition of human KM12 cell growth in a cell viability assay. IC50=22.356 μM	SANGER
HCC2998	Growth inhibition assay		Inhibition of human HCC2998 cell growth in a cell viability assay. IC50=5.52615 μM	SANGER
KNS-42	Growth inhibition assay		Inhibition of human KNS-42 cell growth in a cell viability assay. IC50=35.5826 μM	SANGER
KMOE-2	Growth inhibition assay		Inhibition of human KMOE-2 cell growth in a cell viability assay. IC50=19.2242 μM	SANGER
HCC70	Growth inhibition assay		Inhibition of human HCC70 cell growth in a cell viability assay. IC50=0.57661 μM	SANGER
HEC-1	Growth inhibition assay		Inhibition of human HEC-1 cell growth in a cell viability assay. IC50=3.5895 μM	SANGER
KP-4	Growth inhibition assay		Inhibition of human KP-4 cell growth in a cell viability assay. IC50=42.8832 μM	SANGER
KNS-81-FD	Growth inhibition assay		Inhibition of human KNS-81-FD cell growth in a cell viability assay. IC50=19.5468 μM	SANGER
HGC-27	Growth inhibition assay		Inhibition of human HGC-27 cell growth in a cell viability assay. IC50=31.5873 μM	SANGER
KP-N-YN	Growth inhibition assay		Inhibition of human KP-N-YN cell growth in a cell viability assay. IC50=37.6195 μM	SANGER
KP-N-YS	Growth inhibition assay		Inhibition of human KP-N-YS cell growth in a cell viability assay. IC50=40.6768 μM	SANGER
KU-19-19	Growth inhibition assay		Inhibition of human KU-19-19 cell growth in a cell viability assay. IC50=0.77464 μM	SANGER
HOP-62	Growth inhibition assay		Inhibition of human HOP-62 cell growth in a cell viability assay. IC50=11.6764 μM	SANGER
HOS	Growth inhibition assay		Inhibition of human HOS cell growth in a cell viability assay. IC50=39.6273 μM	SANGER
KURAMOCHI	Growth inhibition assay		Inhibition of human KURAMOCHI cell growth in a cell viability assay. IC50=7.94811 μM	SANGER
KY821	Growth inhibition assay		Inhibition of human KY821 cell growth in a cell viability assay. IC50=0.0206 μM	SANGER
KYSE-270	Growth inhibition assay		Inhibition of human KYSE-270 cell growth in a cell viability assay. IC50=2.02732 μM	SANGER
KYSE-140	Growth inhibition assay		Inhibition of human KYSE-140 cell growth in a cell viability assay. IC50=0.0833 μM	SANGER
KYSE-150	Growth inhibition assay		Inhibition of human KYSE-150 cell growth in a cell viability assay. IC50=42.1782 μM	SANGER
KYSE-450	Growth inhibition assay		Inhibition of human KYSE-450 cell growth in a cell viability assay. IC50=0.05978 μM	SANGER
HT	Growth inhibition assay		Inhibition of human HT cell growth in a cell viability assay. IC50=40.6639 μM	SANGER
KYSE-180	Growth inhibition assay		Inhibition of human KYSE-180 cell growth in a cell viability assay. IC50=0.39089 μM	SANGER
HT-1197	Growth inhibition assay		Inhibition of human HT-1197 cell growth in a cell viability assay. IC50=4.52669 μM	SANGER
KYSE-520	Growth inhibition assay		Inhibition of human KYSE-520 cell growth in a cell viability assay. IC50=5.20839 μM	SANGER
KYSE-70	Growth inhibition assay		Inhibition of human KYSE-70 cell growth in a cell viability assay. IC50=30.5114 μM	SANGER
HUTU-80	Growth inhibition assay		Inhibition of human HUTU-80 cell growth in a cell viability assay. IC50=41.0569 μM	SANGER
L-363	Growth inhibition assay		Inhibition of human L-363 cell growth in a cell viability assay. IC50=16.4577 μM	SANGER
L-428	Growth inhibition assay		Inhibition of human L-428 cell growth in a cell viability assay. IC50=24.5791 μM	SANGER
LAMA-84	Growth inhibition assay		Inhibition of human LAMA-84 cell growth in a cell viability assay. IC50=4.1702 μM	SANGER
HuCCT1	Growth inhibition assay		Inhibition of human HuCCT1 cell growth in a cell viability assay. IC50=10.6034 μM	SANGER
LB1047-RCC	Growth inhibition assay		Inhibition of human LB1047-RCC cell growth in a cell viability assay. IC50=2.74888 μM	SANGER
IGR-1	Growth inhibition assay		Inhibition of human IGR-1 cell growth in a cell viability assay. IC50=28.8874 μM	SANGER
LB2518-MEL	Growth inhibition assay		Inhibition of human LB2518-MEL cell growth in a cell viability assay. IC50=49.8723 μM	SANGER
LB373-MEL-D	Growth inhibition assay		Inhibition of human LB373-MEL-D cell growth in a cell viability assay. IC50=7.76771 μM	SANGER
LB771-HNC	Growth inhibition assay		Inhibition of human LB771-HNC cell growth in a cell viability assay. IC50=35.1658 μM	SANGER
IST-SL1	Growth inhibition assay		Inhibition of human IST-SL1 cell growth in a cell viability assay. IC50=26.6591 μM	SANGER
LCLC-103H	Growth inhibition assay		Inhibition of human LCLC-103H cell growth in a cell viability assay. IC50=36.7803 μM	SANGER
LC-2-ad	Growth inhibition assay		Inhibition of human LC-2-ad cell growth in a cell viability assay. IC50=21.2729 μM	SANGER
LCLC-97TM1	Growth inhibition assay		Inhibition of human LCLC-97TM1 cell growth in a cell viability assay. IC50=4.53686 μM	SANGER
LN-405	Growth inhibition assay		Inhibition of human LN-405 cell growth in a cell viability assay. IC50=22.5913 μM	SANGER
LK-2	Growth inhibition assay		Inhibition of human LK-2 cell growth in a cell viability assay. IC50=13.7639 μM	SANGER
J-RT3-T3-5	Growth inhibition assay		Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay. IC50=6.869 μM	SANGER
LS-1034	Growth inhibition assay		Inhibition of human LS-1034 cell growth in a cell viability assay. IC50=6.20706 μM	SANGER
LS-123	Growth inhibition assay		Inhibition of human LS-123 cell growth in a cell viability assay. IC50=3.74284 μM	SANGER
K5	Growth inhibition assay		Inhibition of human K5 cell growth in a cell viability assay. IC50=1.58357 μM	SANGER
LS-411N	Growth inhibition assay		Inhibition of human LS-411N cell growth in a cell viability assay. IC50=5.79441 μM	SANGER
LU-134-A	Growth inhibition assay		Inhibition of human LU-134-A cell growth in a cell viability assay. IC50=21.1026 μM	SANGER
KG-1	Growth inhibition assay		Inhibition of human KG-1 cell growth in a cell viability assay. IC50=24.1928 μM	SANGER
KINGS-1	Growth inhibition assay		Inhibition of human KINGS-1 cell growth in a cell viability assay. IC50=5.60944 μM	SANGER
LU-65	Growth inhibition assay		Inhibition of human LU-65 cell growth in a cell viability assay. IC50=0.12633 μM	SANGER
LU-139	Growth inhibition assay		Inhibition of human LU-139 cell growth in a cell viability assay. IC50=0.3051 μM	SANGER
LU-99A	Growth inhibition assay		Inhibition of human LU-99A cell growth in a cell viability assay. IC50=37.5731 μM	SANGER
LXF-289	Growth inhibition assay		Inhibition of human LXF-289 cell growth in a cell viability assay. IC50=2.63565 μM	SANGER
M14	Growth inhibition assay		Inhibition of human M14 cell growth in a cell viability assay. IC50=44.1332 μM	SANGER
KNS-62	Growth inhibition assay		Inhibition of human KNS-62 cell growth in a cell viability assay. IC50=3.94731 μM	SANGER
LoVo	Growth inhibition assay		Inhibition of human LoVo cell growth in a cell viability assay. IC50=2.10797 μM	SANGER
KOSC-2	Growth inhibition assay		Inhibition of human KOSC-2 cell growth in a cell viability assay. IC50=3.83451 μM	SANGER
MC-IXC	Growth inhibition assay		Inhibition of human MC-IXC cell growth in a cell viability assay. IC50=11.6728 μM	SANGER
MC116	Growth inhibition assay		Inhibition of human MC116 cell growth in a cell viability assay. IC50=3.95489 μM	SANGER
MDA-MB-175-VII	Growth inhibition assay		Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay. IC50=0.03416 μM	SANGER
MCF7	Growth inhibition assay		Inhibition of human MCF7 cell growth in a cell viability assay. IC50=16.4723 μM	SANGER
MDA-MB-361	Growth inhibition assay		Inhibition of human MDA-MB-361 cell growth in a cell viability assay. IC50=0.72662 μM	SANGER
KS-1	Growth inhibition assay		Inhibition of human KS-1 cell growth in a cell viability assay. IC50=4.50889 μM	SANGER
MDA-MB-157	Growth inhibition assay		Inhibition of human MDA-MB-157 cell growth in a cell viability assay. IC50=2.21828 μM	SANGER
MDA-MB-453	Growth inhibition assay		Inhibition of human MDA-MB-453 cell growth in a cell viability assay. IC50=11.9515 μM	SANGER
KU812	Growth inhibition assay		Inhibition of human KU812 cell growth in a cell viability assay. IC50=0.15456 μM	SANGER
ME-180	Growth inhibition assay		Inhibition of human ME-180 cell growth in a cell viability assay. IC50=1.61096 μM	SANGER
MEG-01	Growth inhibition assay		Inhibition of human MEG-01 cell growth in a cell viability assay. IC50=4.99403 μM	SANGER
KYSE-410	Growth inhibition assay		Inhibition of human KYSE-410 cell growth in a cell viability assay. IC50=1.65672 μM	SANGER
MEL-HO	Growth inhibition assay		Inhibition of human MEL-HO cell growth in a cell viability assay. IC50=30.1423 μM	SANGER
MFE-280	Growth inhibition assay		Inhibition of human MFE-280 cell growth in a cell viability assay. IC50=16.0488 μM	SANGER
MFH-ino	Growth inhibition assay		Inhibition of human MFH-ino cell growth in a cell viability assay. IC50=37.3371 μM	SANGER
KYSE-510	Growth inhibition assay		Inhibition of human KYSE-510 cell growth in a cell viability assay. IC50=19.8748 μM	SANGER
MFM-223	Growth inhibition assay		Inhibition of human MFM-223 cell growth in a cell viability assay. IC50=16.3965 μM	SANGER
MG-63	Growth inhibition assay		Inhibition of human MG-63 cell growth in a cell viability assay. IC50=5.48762 μM	SANGER
MHH-NB-11	Growth inhibition assay		Inhibition of human MHH-NB-11 cell growth in a cell viability assay. IC50=16.0839 μM	SANGER
LAN-6	Growth inhibition assay		Inhibition of human LAN-6 cell growth in a cell viability assay. IC50=40.0112 μM	SANGER
MKN1	Growth inhibition assay		Inhibition of human MKN1 cell growth in a cell viability assay. IC50=3.47108 μM	SANGER
MIA-PaCa-2	Growth inhibition assay		Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay. IC50=28.7959 μM	SANGER
MKN28	Growth inhibition assay		Inhibition of human MKN28 cell growth in a cell viability assay. IC50=32.7838 μM	SANGER
ML-2	Growth inhibition assay		Inhibition of human ML-2 cell growth in a cell viability assay. IC50=0.24802 μM	SANGER
MKN45	Growth inhibition assay		Inhibition of human MKN45 cell growth in a cell viability assay. IC50=21.1551 μM	SANGER
MMAC-SF	Growth inhibition assay		Inhibition of human MMAC-SF cell growth in a cell viability assay. IC50=19.2607 μM	SANGER
MKN7	Growth inhibition assay		Inhibition of human MKN7 cell growth in a cell viability assay. IC50=2.35335 μM	SANGER
LB2241-RCC	Growth inhibition assay		Inhibition of human LB2241-RCC cell growth in a cell viability assay. IC50=0.10884 μM	SANGER
LB831-BLC	Growth inhibition assay		Inhibition of human LB831-BLC cell growth in a cell viability assay. IC50=38.6039 μM	SANGER
MOLT-13	Growth inhibition assay		Inhibition of human MOLT-13 cell growth in a cell viability assay. IC50=0.23975 μM	SANGER
MSTO-211H	Growth inhibition assay		Inhibition of human MSTO-211H cell growth in a cell viability assay. IC50=45.9482 μM	SANGER
MOLT-16	Growth inhibition assay		Inhibition of human MOLT-16 cell growth in a cell viability assay. IC50=17.8935 μM	SANGER
MOLT-4	Growth inhibition assay		Inhibition of human MOLT-4 cell growth in a cell viability assay. IC50=7.02135 μM	SANGER
MZ1-PC	Growth inhibition assay		Inhibition of human MZ1-PC cell growth in a cell viability assay. IC50=30.393 μM	SANGER
MZ2-MEL	Growth inhibition assay		Inhibition of human MZ2-MEL cell growth in a cell viability assay. IC50=16.8403 μM	SANGER
MPP-89	Growth inhibition assay		Inhibition of human MPP-89 cell growth in a cell viability assay. IC50=22.8661 μM	SANGER
MZ7-mel	Growth inhibition assay		Inhibition of human MZ7-mel cell growth in a cell viability assay. IC50=34.6487 μM	SANGER
LNCaP-Clone-FGC	Growth inhibition assay		Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay. IC50=15.4248 μM	SANGER
Mewo	Growth inhibition assay		Inhibition of human Mewo cell growth in a cell viability assay. IC50=34.1349 μM	SANGER
LOXIMVI	Growth inhibition assay		Inhibition of human LOXIMVI cell growth in a cell viability assay. IC50=5.63873 μM	SANGER
NB12	Growth inhibition assay		Inhibition of human NB12 cell growth in a cell viability assay. IC50=25.2947 μM	SANGER
NB10	Growth inhibition assay		Inhibition of human NB10 cell growth in a cell viability assay. IC50=22.2371 μM	SANGER
NB13	Growth inhibition assay		Inhibition of human NB13 cell growth in a cell viability assay. IC50=42.6217 μM	SANGER
NB5	Growth inhibition assay		Inhibition of human NB5 cell growth in a cell viability assay. IC50=1.41317 μM	SANGER
NB14	Growth inhibition assay		Inhibition of human NB14 cell growth in a cell viability assay. IC50=6.43836 μM	SANGER
LS-513	Growth inhibition assay		Inhibition of human LS-513 cell growth in a cell viability assay. IC50=4.31217 μM	SANGER
NB17	Growth inhibition assay		Inhibition of human NB17 cell growth in a cell viability assay. IC50=31.5185 μM	SANGER
NB69	Growth inhibition assay		Inhibition of human NB69 cell growth in a cell viability assay. IC50=1.02945 μM	SANGER
NCI-H1048	Growth inhibition assay		Inhibition of human NCI-H1048 cell growth in a cell viability assay. IC50=2.49158 μM	SANGER
NBsusSR	Growth inhibition assay		Inhibition of human NBsusSR cell growth in a cell viability assay. IC50=3.18254 μM	SANGER
LU-135	Growth inhibition assay		Inhibition of human LU-135 cell growth in a cell viability assay. IC50=33.8829 μM	SANGER
NCI-H1092	Growth inhibition assay		Inhibition of human NCI-H1092 cell growth in a cell viability assay. IC50=16.8316 μM	SANGER
NCI-H1155	Growth inhibition assay		Inhibition of human NCI-H1155 cell growth in a cell viability assay. IC50=19.7238 μM	SANGER
NCI-H1304	Growth inhibition assay		Inhibition of human NCI-H1304 cell growth in a cell viability assay. IC50=26.9108 μM	SANGER
NCI-H1395	Growth inhibition assay		Inhibition of human NCI-H1395 cell growth in a cell viability assay. IC50=20.6697 μM	SANGER
NCI-H1437	Growth inhibition assay		Inhibition of human NCI-H1437 cell growth in a cell viability assay. IC50=18.1641 μM	SANGER
MDA-MB-231	Growth inhibition assay		Inhibition of human MDA-MB-231 cell growth in a cell viability assay. IC50=28.2795 μM	SANGER
MDA-MB-415	Growth inhibition assay		Inhibition of human MDA-MB-415 cell growth in a cell viability assay. IC50=23.9498 μM	SANGER
MHH-ES-1	Growth inhibition assay		Inhibition of human MHH-ES-1 cell growth in a cell viability assay. IC50=27.4447 μM	SANGER
MHH-PREB-1	Growth inhibition assay		Inhibition of human MHH-PREB-1 cell growth in a cell viability assay. IC50=10.1999 μM	SANGER
MLMA	Growth inhibition assay		Inhibition of human MLMA cell growth in a cell viability assay. IC50=22.747 μM	SANGER
MN-60	Growth inhibition assay		Inhibition of human MN-60 cell growth in a cell viability assay. IC50=7.28089 μM	SANGER
MS-1	Growth inhibition assay		Inhibition of human MS-1 cell growth in a cell viability assay. IC50=30.8889 μM	SANGER
MV-4-11	Growth inhibition assay		Inhibition of human MV-4-11 cell growth in a cell viability assay. IC50=3.87994 μM	SANGER
Mo-T	Growth inhibition assay		Inhibition of human Mo-T cell growth in a cell viability assay. IC50=18.8204 μM	SANGER
NB7	Growth inhibition assay		Inhibition of human NB7 cell growth in a cell viability assay. IC50=2.29676 μM	SANGER
NCI-H1299	Growth inhibition assay		Inhibition of human NCI-H1299 cell growth in a cell viability assay. IC50=6.63171 μM	SANGER
NCI-H1355	Growth inhibition assay		Inhibition of human NCI-H1355 cell growth in a cell viability assay. IC50=34.3889 μM	SANGER
NCI-H1792	Growth inhibition assay		Inhibition of human NCI-H1792 cell growth in a cell viability assay. IC50=50.2744 μM	SANGER
NCI-H2347	Growth inhibition assay		Inhibition of human NCI-H2347 cell growth in a cell viability assay. IC50=58.3648 μM	SANGER
NCI-H2452	Growth inhibition assay		Inhibition of human NCI-H2452 cell growth in a cell viability assay. IC50=56.5819 μM	SANGER
PSN1	Growth inhibition assay		Inhibition of human PSN1 cell growth in a cell viability assay. IC50=50.9394 μM	SANGER
RH-1	Growth inhibition assay		Inhibition of human RH-1 cell growth in a cell viability assay. IC50=66.3277 μM	SANGER
SK-LMS-1	Growth inhibition assay		Inhibition of human SK-LMS-1 cell growth in a cell viability assay. IC50=51.9815 μM	SANGER
SK-MEL-30	Growth inhibition assay		Inhibition of human SK-MEL-30 cell growth in a cell viability assay. IC50=133.481 μM	SANGER
SNB75	Growth inhibition assay		Inhibition of human SNB75 cell growth in a cell viability assay. IC50=50.414 μM	SANGER
SNU-423	Growth inhibition assay		Inhibition of human SNU-423 cell growth in a cell viability assay. IC50=70.6017 μM	SANGER
SW1088	Growth inhibition assay		Inhibition of human SW1088 cell growth in a cell viability assay. IC50=50.0201 μM	SANGER
SW1783	Growth inhibition assay		Inhibition of human SW1783 cell growth in a cell viability assay. IC50=52.4982 μM	SANGER
SBC-5	Growth inhibition assay		Inhibition of human SBC-5 cell growth in a cell viability assay. IC50=51.1085 μM	SANGER
A375	Growth inhibition assay		Inhibition of human A375 cell growth in a cell viability assay. IC50=53.6768 μM	SANGER
AM-38	Growth inhibition assay		Inhibition of human AM-38 cell growth in a cell viability assay. IC50=52.9492 μM	SANGER
YH-13	Growth inhibition assay		Inhibition of human YH-13 cell growth in a cell viability assay. IC50=60.0468 μM	SANGER
TYK-nu	Growth inhibition assay		Inhibition of human TYK-nu cell growth in a cell viability assay. IC50=76.6063 μM	SANGER
COLO-668	Growth inhibition assay		Inhibition of human COLO-668 cell growth in a cell viability assay. IC50=60.5077 μM	SANGER
ES6	Growth inhibition assay		Inhibition of human ES6 cell growth in a cell viability assay. IC50=57.7541 μM	SANGER
D-247MG	Growth inhibition assay		Inhibition of human D-247MG cell growth in a cell viability assay. IC50=59.5888 μM	SANGER
H4	Growth inhibition assay		Inhibition of human H4 cell growth in a cell viability assay. IC50=60.5614 μM	SANGER
HMV-II	Growth inhibition assay		Inhibition of human HMV-II cell growth in a cell viability assay. IC50=157.194 μM	SANGER
HT-1080	Growth inhibition assay		Inhibition of human HT-1080 cell growth in a cell viability assay. IC50=62.203 μM	SANGER
IA-LM	Growth inhibition assay		Inhibition of human IA-LM cell growth in a cell viability assay. IC50=54.091 μM	SANGER
K-562	Growth inhibition assay		Inhibition of human K-562 cell growth in a cell viability assay. IC50=50.5633 μM	SANGER
MEL-JUSO	Growth inhibition assay		Inhibition of human MEL-JUSO cell growth in a cell viability assay. IC50=56.1737 μM	SANGER
M059J	Growth inhibition assay		Inhibition of human M059J cell growth in a cell viability assay. IC50=51.0252 μM	SANGER
NB6	Growth inhibition assay		Inhibition of human NB6 cell growth in a cell viability assay. IC50=71.0797 μM	SANGER
NCI-H1975	Proliferation assay	72 h	Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M mutant after 72 hrs by SRB assay, IC50=0.148 μM	24183742
A431	Proliferation assay	72 h	Antiproliferative activity against human A431 cells after 72 hrs by SRB assay, IC50=0.023 nM	24183742
MDA-MB-231	Proliferation assay	72 h	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, EC50=1 nM	20180906
NCI-H1975	Cytotoxicity assay	48 h	Cytotoxicity against human NCI-H1975 cells after 48 hrs by MTT assay, IC50=0.392 μM	20150404
NIH/3T3	Cytotoxicity assay	48 h	Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay, IC50=3.605 μM	20150404
A549	Cytotoxicity assay	72 h	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.05 μM	20180905
PC3	Cytotoxicity assay	72 h	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=4.1 μM	20180905
HeLa	Cytotoxicity assay	72 h	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=6.81 μM	20180905
MCF7	Cytotoxicity assay	72 h	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=5.83 μM	20180905
NSCLC	Cytotoxicity assay	72 h	Cytotoxicity against human NSCLC cells, IC50=0.5 nM	20180905
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Biological Activity

Description

Targets

EGFR (L858R) ^[1] (Cell-free assay)	EGFR (wt) ^[1] (Cell-free assay)	EGFR (L858R/T790M) ^[1] (Cell-free assay)	HER2 ^[1] (Cell-free assay)
0.4 nM	0.5 nM	10 nM	14 nM

In vitro
In vitro	BIBW2992 is more effective than erlotinib, geﬁtinib, or lapatinib in inhibiting survival of lung cancer cell lines harboring wild-type (H1666) or L858R/T790M (NCI-H1975) EGFR. BIBW2992 is similarly effective against NSCLC lines expressing HER2 776insV (NCI-H1781) or EGFR E746_A750del (HCC827), but shows no activity toward A549 cells, which express wild-type EGFR and HER2.^[1] Afatinib enhances cytotoxicity of topotecan and mitoxantrone to SP cells, and increases the apoptosis induced by topotecan and mitoxantrone in SP cells.^[2]
Kinase Assay	In vitro kinase activity assay
Kinase Assay	EGFR kinase: Each 100 µL enzyme reaction contained 10 μL of inhibitor in 50% Me2SO, 20 μL of substrate solution (200 mM HEPES pH 7.4, 50 mM Mg-acetate, 2.5 mg/mL poly (EY), 5 μg/mL bio-pEY) and 20 µL enzyme preparation. The enzymatic reaction is started by addition of 50 µL of a 100 µM ATP solution made in 10 mM MgCl2. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution (250 mM EDTA in 20 mM HEPES pH 7.4). 100 µL are transferred to a streptavidin coated microtiterplate, after an incubation time of 60 min at room temperature the plate is washed with 200 µL of wash solution (50 mM Tris, 0.05% Tween20). A 100 µL aliquot of a HRPO- labeled anti-PY antibody (PY20H Anti-Ptyr:HRP ) 250 ng/mL are added to the wells. After 60 min of incubation, the plate is washed three times with a 200 µL wash solution. The samples are then developed with a 100µL TMB Peroxidase Solution (A:B= 1:1). The reaction is stopped after 10 min. The plate is transferred to an ELISA reader and extinction is measured at OD450nm. HER2-IC enzyme: Enzyme activity is assayed in the presence or absence of serial inhibitor dilutions performed in 50 % Me2SO. Each 100 µL reaction contains similar components as described for EGFR kinase assay with addition of 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50µL of 500 µM ATP solution made in 10 mM Mg-acetate. The dilution of the enzyme is set so that incorporation of phosphate into bio-pEY is linear with respect to time and amount of enzyme. The enzyme preparation is diluted in 20 mM HEPES pH 7.4, 130 mM NaCl, 0.05% Triton X-100, 1 mM DTT and 10% glycerol. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution. Src kinase assays: Each 100 µL reaction contained 10 µL of inhibitor in 50 % Me2SO, 20µL of enzyme preparation, 20 µL of substrate solution supplemented with 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50 µL of a 1000 µM ATP solution made in 10 mM Mg-acetate. BIRK kinase assay: 250 mM Tris pH 7.4, 10mM DTT, 2.5 mg/mL poly(EY), 5 mg/mL bio-pEY is used as substrate solution and enzymatic reaction is started by addition of 50 µL of a 2 mM ATP solution made in 8 mM MnCl2, 20 mM Mg-acetate. VEGF2 and HGFR kinase assays: Assays are carried out at room temperature for 20 minutes and terminated by the addition of 10 µL of 5 % H3PO4. The precipitate is then trapped onto GF/B filters using a 96 well filter mate universal harvester. After extensive washing the filter plate is dried for 1 h at 50°C, sealed and incorporated radioactivity is determined by scintillation counting using a TopCount™ or a Microbeta b counter™.
Cell Research	Cell lines	SP and NSP cell lines
	Concentrations	1 μM
	Incubation Time	48 h
	Method	Cytotoxicity is determined using MTT assay. The IC 50 value is deﬁned as the drug concentration resulting in 50% cell death. Both the ﬁtted sigmoidal dose response curve and IC50 are calculated by Bliss method.
Experimental Result Images	Methods	Biomarkers	Images	PMID
	Growth inhibition assay	Cell apoptosis Cell viability		25537503
	Western blot	CIP2A / p-AKT / AKT / PARP p-EGFR / p-IGF1R / p-ERK / p-AKT		25537503
	Immunofluorescence	p65 vacuoles		26317651

In Vivo
In vivo	In the MDA-MB-453 xenograft model, BIBW2992 (20 mg/kg, p.o.) results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%, and downregulation of EGFR and AKT phosphorylation.^[1] In A7, A431, FaDu, UT-SCC-14 and UT-SCC-15 xenograft models, application of BIBW 2992 (30 mg/kg, p.o.) leads to a significant prolongation of tumour growth time.^[3] In HER2-amplified xenograft medel, Afatinib (30 mg/kg, p.o.) results a markedly inhibition in tumor growth and a significant improvement in the duration of overall survival.^[4] In HER2-positive gastric cancer NCI-N87 xenograft, afatinib (25 mg/kg, p.o.) leads to dramatic tumor volume regression within 4 d and near-complete tumor resolution after 21 d of treatment.^[5]
Animal Research	Animal Models	SCID mice harbouring ARK2 xenografts
	Dosages	25 mg/kg
	Administration	p.o.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05298176	Recruiting	Non-Small Cell Lung Cancer	Amsterdam UMC location VUmc	January 4 2022	Phase 2
NCT04795245	Completed	Non-squamous Non-Small Cell Lung Cancer	Boehringer Ingelheim	August 26 2021	--
NCT04497584	Recruiting	Advanced Squamous Non Small Cell Lung Cancer	University of Texas Southwestern Medical Center	August 4 2021	Phase 2
NCT04413201	Active not recruiting	Non-squamous NSCLC	Michael Hopp\|Boehringer Ingelheim\|Johannes Gutenberg University Mainz	September 11 2020	Phase 4

References

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Chemical lnformation & Solubility

Molecular Weight	717.18	Formula	C₂₄H₂₅ClFN₅O₃.2C₄H₄O₄
CAS No.	850140-73-7	SDF	Download Afatinib Dimaleate SDF
Smiles	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (139.43 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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