Home Endocrinology & Hormones Androgen Receptor inhibitor - CDK inhibitor - ATM/ATR activator - PI3K modulator - Akt modulator - Apoptosis related activator - p21 agonist Ailanthone For research use only.

Ailanthone

Synonyms: AIL, Δ13-Dehydrochaparrinone

Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.

Ailanthone Chemical Structure

Ailanthone Chemical Structure

CAS: 981-15-7

Selleck's Ailanthone has been cited by 1 publication

Purity & Quality Control

Batch: S688501 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.87%
99.87

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Biological Activity

Description Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.
Targets
CDK [1] p21 [1] ATM/ATR [1] Akt [1] PI3K [1] Click to View More Targets

Chemical lnformation & Solubility

Molecular Weight 376.40 Formula

C20H24O7
CAS No. 981-15-7 SDF --
Smiles CC1=CC(=O)C(C2(C1CC3C45C2C(C(C(=C)C4CC(=O)O3)O)(OC5)O)C)O
Storage (From the date of receipt) 3 years -20°C powder

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