Home Neuronal Signaling Dopamine Receptor antagonist Alizapride HCl For research use only.

Alizapride HCl

Synonyms: Alizapride hydrochloride

Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

Alizapride HCl Chemical Structure

Alizapride HCl Chemical Structure

CAS: 59338-87-3

Purity & Quality Control

Batch: S425701 Water] 70 mg/mL] false] DMSO] 42 mg/mL] false] Ethanol] Insoluble] false Purity: 99.08%
99.08

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Biological Activity

Description Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
Targets
Dopamine receptor [1]
In vitro
In vitro

Alizapride has a N-allyl moiety which potentially could undergo N-deallylation and/or epoxidation reactions, the formation of chemically reactive metabolites can be expected. [1]
In Vivo
In vivo

Alizapride demonstrates little toxicity (particularly after parenteral administration) in mice and rats. Alizapride is mainly excreted as unmodified drug after oral or parenteral administration; however, a share of about 25% undergoes metabolic transformation before deletion. [1] Alizapride (5 mg/kg, s.c.) antagonizes the decrease in gastrointestinal transit induced by the above doses of Apomorphine in the rat. [2]

Chemical lnformation & Solubility

Molecular Weight 351.83 Formula

C16H21N5O2.HCl
CAS No. 59338-87-3 SDF Download Alizapride HCl SDF
Smiles COC1=CC2=C(C=C1C(=O)NCC3CCCN3CC=C)NN=N2.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 70 mg/mL

DMSO : 42 mg/mL ( (119.37 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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