Home Metabolism Dehydrogenase inhibitor - STING agonist Alpha-Mangostin For research use only.

Alpha-Mangostin

Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.

Alpha-Mangostin Chemical Structure

Alpha-Mangostin Chemical Structure

CAS: 6147-11-1

Selleck's Alpha-Mangostin has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 98.56%
98.56

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Biological Activity

Description Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
In vitro
In vitro α-mangostin shows both fast-binding and slow-binding inhibitions to FAS in vitro. It inhibits FAS overall reaction with a half-inhibitory concentration (IC50) value of 5.54 μM non-competitively with respect to NADPH, and partially competitively against both substrates acetyl-CoA and malonyl-CoA. α-Mangostin could reduce cell viability and induce apoptosis in human breast cancer cells[1]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM H2O2-induced apoptosis of RPE cells. Alpha-mangostin can activate the expression of PKC-δ and down-regulate the expression of mitogen-activated protein kinases (MAPKs), including ERK1/2, JNK, P38[2].
Cell Research Cell lines human breast cancer MCF-7 and MDA-MB-231 cells
Concentrations 0, 1, 2, 3, 4, 6, 8, and 10 μM
Incubation Time 24 h and 48 h
Method MCF-7 and MDA-MB-231 cells are treated with 0, 1, 2, 3, 4, 6, 8, and 10 μM α-mangostin for 24 h and 48 h. Cell viability is then determined by the CCK-8 assay.
In Vivo
In vivo Alpha-mangostin stimulation results in an increase of superoxide dismutase (SOD) activity, glutathione peroxidase (GPX) activity and glutathione (GSH) content both in vivo and vitro. It suppresses light-induced retina dysfunction. Alpha-mangostin has protective effect on kidney, heart and brain tissues against oxidative stress[2].
Animal Research Animal Models Female balb/c mice, aged 8 weeks
Dosages 10 mg/kg (lower-dose) or 30 mg/kg body weight (higher-dose)
Administration intragastric administration

Chemical lnformation & Solubility

Molecular Weight 410.46 Formula

C24H26O6
CAS No. 6147-11-1 SDF Download Alpha-Mangostin SDF
Smiles CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)OC)CC=C(C)C)O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (199.77 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 82 mg/mL

Water : Insoluble


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In vivo
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