Home Microbiology Influenza Virus inhibitor Amantadine For research use only.

Amantadine

Synonyms: 1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane

Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.

Amantadine Chemical Structure

Amantadine Chemical Structure

CAS: 768-94-5

Purity & Quality Control

Batch: S549901 4-Methylpyridine] 10 mg/mL] true] DMSO] 1 mg/mL] false] ] ] false Purity: 98%
98

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Biological Activity

Description Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.
Targets
M2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04530006 Recruiting Glioblastoma Multiforme CancerCare Manitoba|University of Manitoba|The Metabolomics Innovation Centre|BioMark Diagnostics Inc.|Canadian Institutes of Health Research (CIHR) December 2 2020 Not Applicable
NCT02277938 Unknown status Cancer University of Manitoba|BioMark Technologies Inc.|St. Boniface Hospital August 2013 --
NCT01491529 Completed Dyskinesias|Parkinson Disease|Movement Disorders|Parkinsonian Disorders|Anti-Dyskinesia Agents Novartis Pharmaceuticals|Novartis April 2012 Phase 2
NCT01467258 Completed Healthy Metabolism University of Manitoba|St. Boniface Hospital November 2011 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 151.25 Formula

C10H17N
CAS No. 768-94-5 SDF --
Smiles C1C2CC3CC1CC(C2)(C3)N
Storage (From the date of receipt)

In vitro
Batch:

4-Methylpyridine : 10 mg/mL

DMSO : 1 mg/mL ( (6.61 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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