Home GPCR & G Protein Taste Receptor agonist - TNF-alpha inhibitor - Apoptosis related activator - PI3K inhibitor - Akt inhibitor - AMPK activator Amarogentin For research use only.

Amarogentin

Synonyms: AG

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.

Amarogentin Chemical Structure

Amarogentin Chemical Structure

CAS: 21018-84-8

Purity & Quality Control

Batch: S127301 DMSO] 100 mg/mL] false] Ethanol] 50 mg/mL] false] Water] Insoluble] false Purity: 99.17%
99.17

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Biological Activity

Description

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.
Targets
TAS2R1 [2] TNF-α [2] AMPK [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05940766 Not yet recruiting Pediatric Oncology Patients With Risk for Infections Insel Gruppe AG University Hospital Bern|ETH Zurich October 1 2024 Not Applicable
NCT05391841 Not yet recruiting Cartilage Disease Tetec AG|Winicker Norimed GmbH May 31 2024 --
NCT05540223 Not yet recruiting Coronary Artery Disease|Atherosclerosis Coronary|Myocardial Ischemia|Ischemic Heart Disease|Acute Coronary Syndrome|Angina Pectoris Biotronik AG April 2024 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 586.54 Formula

C29H30O13
CAS No. 21018-84-8 SDF --
Smiles OCC1OC(OC2OC=C3C(CCOC3=O)C2C=C)C(OC(=O)C4=C(O)C=C(O)C=C4C5=CC=CC(=C5)O)C(O)C1O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (170.49 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : Insoluble


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