Home Immunology & Inflammation NOS inhibitor Amcinonide For research use only.

Amcinonide

Synonyms: Cyclocort, CL-34699

Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.

Amcinonide Chemical Structure

Amcinonide Chemical Structure

CAS: 51022-69-6

Purity & Quality Control

Batch: S567101 DMSO] 84 mg/mL] false] Water] 84 mg/mL] false] Ethanol] 84 mg/mL] false Purity: 99.95%
99.95

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Biological Activity

Description Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.
Targets
NO [1]
(Cell-free assay)
3.38 nM
In vitro
In vitro Amcinonide treatment leads to a significant up-regulation of Gli1 expression, while all the other compounds tested have minor or no effects. [2]

Chemical lnformation & Solubility

Molecular Weight 502.57 Formula

C28H35FO7
CAS No. 51022-69-6 SDF --
Smiles CC(=O)OCC(=O)C12OC3(CCCC3)OC1CC4C5CCC6=CC(=O)C=CC6(C)C5(F)C(O)CC24C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 84 mg/mL ( (167.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 84 mg/mL

Ethanol : 84 mg/mL


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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