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Amikacin disulfate

Name: Amikacin disulfate
Brand: Selleck Chemicals
SKU: S3065
Rating: 5 (1 reviews)

Synonyms: BB-K8

Catalog No.S3065 Purity: 99.68%

Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.

Amikacin disulfate Chemical Structure

CAS: 39831-55-5

Selleck's Amikacin disulfate has been cited by 1 publication

Purity & Quality Control

Batch: S306501 Water] 10 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.68%

99.68

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Biological Activity

Description

Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.

Targets

16S rRNA ^[1]

In vitro
In vitro	Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. ^[1] Amikacin is active in vitro against Pseudomonas species, ^[2] Escherichia coli^[3], Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii.^[4] ^[5] In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms. ^[6]

In Vivo
In vivo	Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. ^[7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly. ^[8]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05555303	Recruiting	Tuberculosis Multidrug-Resistant	Rwanda Biomedical Centre\|Institute of Tropical Medicine\|World Health Organization	March 1 2023	Phase 2
NCT05689450	Recruiting	Febrile Neutropenia (FN)	University Hospital Basel Switzerland	December 21 2022	--
NCT05593601	Recruiting	Colonization Asymptomatic	Mahidol University	November 24 2022	Phase 4
NCT05511129	Active not recruiting	COVID-19\|Nosocomial Infection	Fondation Hôpital Saint-Joseph	May 12 2022	--
NCT04239326	Completed	Tuberculosis Multidrug-Resistant	Foundation for Innovative New Diagnostics Switzerland	April 16 2021	--

References

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Chemical lnformation & Solubility

Molecular Weight	781.76	Formula	C₂₂H₄₃N₅O₁₃.2H₂SO₄
CAS No.	39831-55-5	SDF	Download Amikacin disulfate SDF
Smiles	C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 10 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

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