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Ampicillin Trihydrate

Name: Ampicillin Trihydrate
Brand: Selleck Chemicals
SKU: S4148
Rating: 5 (2 reviews)

Synonyms: NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate

Catalog No.S4148 Purity: 99.95%

Ampicillin Trihydrate (NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Ampicillin Trihydrate Chemical Structure

CAS: 7177-48-2

Selleck's Ampicillin Trihydrate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.95%

99.95

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Choose Selective Antibiotics for Mammalian Cell Culture Inhibitors

Biological Activity

Description

Features

More effective than levofloxacin and ciprofloxacin against Streptococcus pneumoniae.

Targets

beta-lactamase ^[1]

In vitro
In vitro	Ampicillin Trihydrate (500 mg) results in rapid bactericidal effect for SP34, the concentrations declines to the limit of detection (100 CFU/mL) during the initial 6 hours, and regrowth is not observed over the remaining 18 hours. ^[1]

In Vivo
In vivo	Ampicillin Trihydrate (10 mg/kg) results in half life (t _1/2) of 1.2 hours in goats and 2.48 hours in sheep, clearance (Cl) of 2921 mL/h·kg in goats and 262 mL/h·kg in sheep, ampicillin volume of distribution (Vdarea) of 5673 mL/kg in goats and 992 mL/kg in sheep. ^[2] Ampicillin Trihydrate (0.18 kg/kg-3 kg/kg) results in no dose-related mortality, normal body weights, no compound-related gross or histopathologic lesions and diarrhea in mice and rats. ^[3] Ampicillin in combination of norfloxacin, at a dose of 1g/L, maximally suppresses the numbers of cecal aerobic and anaerobic bacteria in ob/ob mice. Ampicillin in combination of norfloxacin results in a significant improvement in fasting glycemia and oral glucose tolerance reduced liver triglycerides and increased liver glycogen and concomitant reduction of plasma lipopolysaccharides in ob/ob mice. ^[4] Ampicillin trihydrate (20 mg/kg) treats five foals, the mean peak serum ampicillin concentration at two to three days old is 5.0 μg/mL at 1 hours after treatment, the mean peak serum concentration at 16 days to 21 days old is 2.7 μg/mL at 2 hours, the concentrations steadily declines and ampicillin is not detected in the serum from any of the foals by 24 hours, and serum clearance averages 17.7 mL/min/kg at two to three days and 35.8 mL/min/kg at 16 days to 21 days. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04647331	Recruiting	Infective Endocarditis	Uppsala University	June 1 2021	--
NCT03129620	Completed	Hypothermia	Drexel University	March 2013	--
NCT01433757	Completed	DYT-1\|Dystonia	University of Florida\|Tyler''s Hope for a Dystonia Cure Inc	September 2011	Phase 1
NCT01118403	Withdrawn	Ventilator Associated Pneumonia	Hospital Pablo Tobón Uribe	March 2011	Phase 4

References

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Chemical lnformation & Solubility

Molecular Weight	403.45	Formula	C₁₆H₁₉N₃O₄S.3H₂O
CAS No.	7177-48-2	SDF	Download Ampicillin Trihydrate SDF
Smiles	CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C.O.O.O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 81 mg/mL ( (200.76 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 2 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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