Home Metabolism PDE inhibitor Anagrelide HCl For research use only.

Anagrelide HCl

Synonyms: BL-4162A,BMY 26538-01

Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.

Anagrelide HCl Chemical Structure

Anagrelide HCl Chemical Structure

CAS: 58579-51-4

Selleck's Anagrelide HCl has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

Other PDE Products

Related compound libraries

Choose Selective PDE Inhibitors

Biological Activity

Description Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.
Targets
PDE [1]
In vitro
In vitro

Anagrelide is an oral imidazoquinazoline agent with an anti-cyclic AMP phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03866434 Completed Healthy Volunteers Shire|Takeda February 26 2019 Phase 1
NCT02125318 Completed Thrombocytosis|Myeloproliferative Neoplasms Galena Biopharma Inc. May 2014 Phase 2
NCT01192347 Completed Essential Thrombocythemia Shire|Takeda September 13 2010 --

Chemical lnformation & Solubility

Molecular Weight 292.55 Formula

C10H7Cl2N3O.HCl
CAS No. 58579-51-4 SDF Download Anagrelide HCl SDF
Smiles C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 14 mg/mL ( (47.85 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Anagrelide HCl | Anagrelide HCl ic50 | Anagrelide HCl price | Anagrelide HCl cost | Anagrelide HCl solubility dmso | Anagrelide HCl purchase | Anagrelide HCl manufacturer | Anagrelide HCl research buy | Anagrelide HCl order | Anagrelide HCl mouse | Anagrelide HCl chemical structure | Anagrelide HCl mw | Anagrelide HCl molecular weight | Anagrelide HCl datasheet | Anagrelide HCl supplier | Anagrelide HCl in vitro | Anagrelide HCl cell line | Anagrelide HCl concentration | Anagrelide HCl nmr