Home Metabolism Retinoid Receptor inhibitor AR7 For research use only.

AR7

AR7 is a retinoic acid receptor α (RARα) antagonist.

AR7 Chemical Structure

AR7 Chemical Structure

CAS: 80306-38-3

Purity & Quality Control

Batch: S660501 DMSO] 4 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.87%
99.87

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Biological Activity

Description AR7 is a retinoic acid receptor α (RARα) antagonist.
In vitro
In vitro

AR7 significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA.[1]
Cell Research Cell lines Mouse fibroblasts
Concentrations 0-10 μM, 20μM
Incubation Time 16 h
Method

Mouse fibroblasts expressing the KFERQ-mcherry1 photoactivable reporter with or without AR7 (20μM) imaged 16 h after photoactivation.
In Vivo
In vivo

Reactivation of CMA by treatment with AR7 inhibits diclofenac-induced lipid accumulation and hepatotoxicity. [2]

Chemical lnformation & Solubility

Molecular Weight 257.71 Formula

C15H12ClNO
CAS No. 80306-38-3 SDF --
Smiles CC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 4 mg/mL ( (15.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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