Home Microbiology Parasite inhibitor Arteether For research use only.

Arteether

Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.

Arteether Chemical Structure

Arteether Chemical Structure

CAS: 75887-54-6

Selleck's Arteether has been cited by 1 publication

Purity & Quality Control

Batch: S388901 DMSO] 62 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Biological Activity

Description Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.
In vitro
In vitro Arteether is an oil-soluble derivative of artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. Arteether and other derivatives show a dose-dependent manner to interact with immune cells[1].
In Vivo
In vivo Intratumoral injection of Arteether could have a significant reduction in tumor growth rate. Intra-tumoral injection of Arteether, as a loco-regional administration, may yield higher drug concentration in tumor and may reduce the risk of systemic adverse effects[1].
Animal Research Animal Models Balb/c mice
Dosages 6 mg/kg/day
Administration via intratumoral (IT) route

Chemical lnformation & Solubility

Molecular Weight 312.40 Formula

C17H28O5
CAS No. 75887-54-6 SDF Download Arteether SDF
Smiles CCOC1C(C2CCC(C3C24C(O1)OC(CC3)(OO4)C)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (198.46 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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