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AS057278

Synonyms: 3-Methylpyrazole-5-carboxylic acid

AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).

AS057278 Chemical Structure

AS057278 Chemical Structure

CAS: 402-61-9

Purity & Quality Control

Batch: S543401 DMSO] 25 mg/mL] false] ] ] false] ] ] false Purity: 99.96%
99.96

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Biological Activity

Description AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).
Targets
DAAO [2]
0.91 μM
In vitro
In vitro No inhibitory effect on DASOX were observed with AS057278 at the concentration of 10 μM and no inhibitory effect on serine racemase were observed with AS057278 at the concentration of 50 μM[2].
In Vivo
In vivo MPC is able to increase brain d-serine levels and ameliorate PCP-induced abnormal behavior in SD rat[1]. MPC increaseS D-serine fraction in rat cortex and midbrain (10 mg/kg i.v.). AS057278 was able to normalize phencyclidine (PCP)-induced prepulse inhibition after acute (80 mg/kg) and chronic (20 mg/kg b.i.d.) oral administration in mice. AS057278 after oral chronic treatment (10 mg/kg b.i.d.) was able to normalize PCP-induced hyperlocomotion[2].
Animal Research Animal Models Male SD rats
Dosages 5.0 or 50 mg/kg
Administration i.p.

Chemical lnformation & Solubility

Molecular Weight 126.11 Formula

C5H6N2O2
CAS No. 402-61-9 SDF --
Smiles CC1=CC(=NN1)C(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 25 mg/mL ( (198.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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