Home Neuronal Signaling 5-HT Receptor inhibitor Atomoxetine HCl For research use only.

Atomoxetine HCl

Synonyms: LY 139603 HCl

Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

Atomoxetine HCl Chemical Structure

Atomoxetine HCl Chemical Structure

CAS: 82248-59-7

Purity & Quality Control

Batch: S317501 DMSO] 58 mg/mL] false] Ethanol] 37 mg/mL] false] Water] 2 mg/mL] false Purity: 99.96%
99.96

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Biological Activity

Description Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
Targets
Norepinephrine (NE) transporter [1] 5-HT [1] DA transporter [1]
5 nM(Ki) 77 nM(Ki) 1451 nM(Ki)
In vitro
In vitro Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters. [1]
In Vivo
In vivo In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold, but does not alter DAEX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. [1] Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression. [2][3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03154359 Completed ADHD Children''s Mercy Hospital Kansas City|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) December 12 2017 --
NCT03460210 Recruiting Obesity Morbid Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital November 2 2016 --
NCT01522404 Completed Mild Cognitive Impairment Emory University|National Institute on Aging (NIA) March 2012 Phase 2
NCT01709695 Completed ADHD|Attention Deficit Hyperactivity Disorder Icahn School of Medicine at Mount Sinai March 2011 Phase 4

Chemical lnformation & Solubility

Molecular Weight 291.82 Formula

C17H21NO.HCl
CAS No. 82248-59-7 SDF Download Atomoxetine HCl SDF
Smiles CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 58 mg/mL ( (198.75 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 37 mg/mL

Water : 2 mg/mL


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