Home Microbiology Bacterial inhibitor - Thioredoxin Reductase inhibitor Auranofin For research use only.

Auranofin

Synonyms: SKF39162

Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.

Auranofin Chemical Structure

Auranofin Chemical Structure

CAS: 34031-32-8

Selleck's Auranofin has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 100.00%
100.00

Related compound libraries

Choose Selective Bacterial Inhibitors

Biological Activity

Description Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
Targets
TrxR [1]
(Cell-free assay)
88 nM
In vitro
In vitro

Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay.
In Vivo
In vivo

Auranofin is a small molecule inhibitor of NONO that suppressed GBM tumor growth in an orthotopic xenograft model in mice.
Animal Research Animal Models Athymic nude mice
Dosages 5 or 10 mg/kg
Administration o.g.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02089048 Completed Amoebiasis National Institute of Allergy and Infectious Diseases (NIAID) April 2 2014 Phase 1
NCT01747798 Completed Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer Mayo Clinic November 2 2012 Early Phase 1
NCT01419691 Completed Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma|Leukemia Prolymphocytic University of Kansas Medical Center|The Leukemia and Lymphoma Society|Kansas Bioscience Authority|Therapeutics for Rare and Neglected Diseases (TRND) September 2011 Phase 2
NCT02176135 Withdrawn HIV Vaccine and Gene Therapy Institute Florida|University of Miami Phase 1|Phase 2

Chemical lnformation & Solubility

Molecular Weight 678.48 Formula

C20H34AuO9PS
CAS No. 34031-32-8 SDF Download Auranofin SDF
Smiles CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (147.38 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Auranofin | Auranofin supplier | purchase Auranofin | Auranofin cost | Auranofin manufacturer | order Auranofin | Auranofin distributor