Home Immunology & Inflammation Immunology & Inflammation related antagonist - CD markers antagonist Avacopan For research use only.

Avacopan

Synonyms: CCX168

Avacopan is an orally administered and selective C5a receptor (C5aR) antagonist.

Avacopan Chemical Structure

Avacopan Chemical Structure

CAS: 1346623-17-3

Selleck's Avacopan has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.04%
99.04

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Biological Activity

Description Avacopan is an orally administered and selective C5a receptor (C5aR) antagonist.
Targets
C5aR [1]
In vitro
In vitro

Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.
Cell Research Cell lines RAW 264.7 cells
Concentrations 1 µM
Incubation Time 24 h
Method

Cells were treated with indicated concentrations of drug for 24 h.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05897684 Recruiting ANCA-associated Vasculitis Vifor Fresenius Medical Care Renal Pharma September 11 2023 --
NCT06004934 Completed Hepatic Impairment Amgen April 17 2018 Phase 1
NCT05988008 Completed Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Amgen October 23 2017 Phase 1

Chemical lnformation & Solubility

Molecular Weight 581.64 Formula

C33H35F4N3O2
CAS No. 1346623-17-3 SDF --
Smiles CC1=C(C(=CC=C1)F)C(=O)N2CCCC(C2C3=CC=C(C=C3)NC4CCCC4)C(=O)NC5=CC(=C(C=C5)C)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (171.92 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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