Home Immunology & Inflammation TpoR agonist Avatrombopag For research use only.

Avatrombopag

Synonyms: AKR-501,E5501,YM477

Avatrombopag (AKR-501,E5501,YM477) is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation.

Avatrombopag Chemical Structure

Avatrombopag Chemical Structure

CAS: 570406-98-3

Purity & Quality Control

Batch: Purity: 99.96%
99.96

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Biological Activity

Description Avatrombopag (AKR-501,E5501,YM477) is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05772546 Not yet recruiting Gastrointestinal Cancer|Gastrointestinal Neoplasms|Chemotherapy-Induced Thrombocytopenia Hanny Al-Samkari MD|Swedish Orphan Biovitrum|Massachusetts General Hospital September 2023 Phase 2
NCT04312789 Withdrawn Platelet Disorder Ayman Saad|Sobi Inc.|Ohio State University Comprehensive Cancer Center December 2022 Phase 2
NCT05518331 Recruiting Refractory Aplastic Anemia Institute of Hematology & Blood Diseases Hospital China|Peking University People''s Hospital|Xiyuan Hospital of China Academy of Chinese Medical Sciences|Second Hospital of Shanxi Medical University|First Affiliated Hospital of Harbin Medical University|The First Hospital of Hebei Medical University June 1 2022 Not Applicable
NCT05218226 Recruiting Chemotherapy-induced Thrombocytopenia|Avatrombopag Institute of Hematology & Blood Diseases Hospital China|Tianjin Medical University Cancer Institute and Hospital|Tianjin Medical University Second Hospital|Tianjin Third Central Hospital|Tianjin People''s Hospital|Henan Cancer Hospital|The Second Affiliated Hospital of Kunming Medical University February 10 2022 Phase 2
NCT04949009 Unknown status Primary Immune Thrombocytopenia Shandong University March 1 2021 --
NCT04609891 Completed Thrombocytopenia Anhui Provincial Cancer Hospital May 26 2020 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 649.65 Formula

C29H34Cl2N6O3S2
CAS No. 570406-98-3 SDF --
Smiles C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 20 mg/mL ( (30.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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