Home Microbiology Anti-infection inhibitor Azodicarbonamide For research use only.

Azodicarbonamide

Synonyms: ADA, HPH-116, NSC 674447

Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Azodicarbonamide Chemical Structure

Azodicarbonamide Chemical Structure

CAS: 123-77-3

Purity & Quality Control

Batch: S243001 DMSO] 23 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 98.23%
98.23

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Biological Activity

Description Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
nucleocapsid CCHC domains [1] HIV-1 [1]
(Cell-based assay)
38 μM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05986721 Not yet recruiting Mild Cognitive Impairment|Prodromal Alzheimer''s Disease AgeneBio December 2024 Phase 3
NCT04760860 Not yet recruiting Dementia With Lewy Bodies Qiang Zhang|University of Iowa October 2024 Phase 1|Phase 2
NCT06054113 Not yet recruiting B Precursor Acute Lymphoblastic Leukemia|Relapsed/Refractory B Precursor Acute Lymphoblastic Leukemia Amgen June 21 2024 Phase 2
NCT05646524 Not yet recruiting Paroxysmal Nocturnal Hemoglobinuria NovelMed Therapeutics May 2024 Phase 2

Chemical lnformation & Solubility

Molecular Weight 116.08 Formula

C2H4N4O2
CAS No. 123-77-3 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 23 mg/mL ( (198.13 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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