Home Neuronal Signaling 5-HT Receptor agonist Buspirone HCl For research use only.

Buspirone HCl

Synonyms: Buspirone hydrochloride

Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.

Buspirone HCl Chemical Structure

Buspirone HCl Chemical Structure

CAS: 33386-08-2

Selleck's Buspirone HCl has been cited by 1 publication

Purity & Quality Control

Batch: S425601 DMSO] 84 mg/mL] false] Water] 84 mg/mL] false] Ethanol] 36 mg/mL] false Purity: 99.99%
99.99

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Biological Activity

Description Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.
Targets
5-HT1A [1]
In vitro
In vitro

Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. [1] Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine. [2]
In Vivo
In vivo

Buspirone (3 mg/rat, i.p.) dose dependently and completely inhibits shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus of rats, a brain region rich in somatodendritic 5-HT1A receptors. [3] Buspirone (20 mg/kg) decreases immobility in the rat forced swim test. [4] Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect in a zebrafish model of anxiety. [5] Buspirone dose-dependently reduces LID and improved l-DOPA-related motor performance due to action at the 5-HT(1A) receptor in l-DOPA-primed rats. Buspirone delayes LID development while improving l-DOPA's anti-parkinsonian efficacy indicating the potential long-term benefits of 5-HT(1A) agonists for reduction of l-DOPA-related side effects in l-DOPA-naive rats. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05511909 Recruiting Opioid Use Disorder|Opioid Withdrawal|Opioid Craving|Anxiety Johns Hopkins University December 15 2022 Phase 2
NCT03444831 Completed Dyspepsia Isfahan University of Medical Sciences March 1 2016 Phase 4
NCT02483598 Terminated Gastric Bypass North Dakota State University|Neuropsychiatric Research Institute Fargo North Dakota June 2015 Phase 4
NCT01699828 Completed Smoking Cessation|Tobacco Use Cessation Centre for Addiction and Mental Health October 2012 Phase 1|Phase 2
NCT01496612 Terminated Anxiety Disorder|Seizures|Epilepsy|Partial Epilepsy|Depression National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) November 22 2011 Phase 2
NCT00873509 Completed Autistic Disorder Chugani Diane C.|National Institute of Neurological Disorders and Stroke (NINDS) May 2009 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 421.96 Formula

C21H31N5O2.HCl
CAS No. 33386-08-2 SDF Download Buspirone HCl SDF
Smiles C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 84 mg/mL ( (199.07 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 84 mg/mL

Ethanol : 36 mg/mL


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In vivo
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