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Ceftaroline Fosamil

Name: Ceftaroline Fosamil
Brand: Selleck Chemicals
SKU: S4417

Synonyms: CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo

Catalog No.S4417 Purity: 99.98%

Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

Ceftaroline Fosamil Chemical Structure

CAS: 400827-46-5

Purity & Quality Control

Batch: S441701 DMSO] 73 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.98%

99.98

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Biological Activity

Description	Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01789528	Completed	Pharmacokinetics\|Open Label\|CAZ-AVI\|CXL\|Effect on Intestinal Flora\|Safety	Pfizer	August 2013	Phase 1
NCT01701219	Completed	Staphylococcus Aureus Bacteremia\|Methicillin-resistant Staphylococcus Aureus (MRSA) Bacteremia	Forest Laboratories	January 2013	Phase 4
NCT01666743	Withdrawn	Community-Acquired Bacterial Pneumonia (CABP)	Forest Laboratories	November 2012	Phase 4
NCT01612507	Completed	Healthy Volunteers	Pfizer	July 2012	Phase 1

References

[1] Amira A Bhalodi, et al. Antimicrob Agents Chemother. 2012 Dec;56(12):6160-5.

Chemical lnformation & Solubility

Molecular Weight	744.74	Formula	C₂₄H₂₅N₈O₁₀PS₄
CAS No.	400827-46-5	SDF	--
Smiles	CCO\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)SC3=NC(=CS3)C4=CC=[N+](C)C=C4)C5=NSC(=N5)N[P](O)(O)=O.CC([O-])=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 73 mg/mL ( (98.02 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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