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Cetylpyridinium Chloride

Name: Cetylpyridinium Chloride
Brand: Selleck Chemicals
SKU: S4172
Rating: 5 (1 reviews)

Synonyms: CPC

Catalog No.S4172 Purity: 99.79%

Cetylpyridinium chloride(CPC) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.

Cetylpyridinium Chloride Chemical Structure

CAS: 123-03-5

Selleck's Cetylpyridinium Chloride has been cited by 1 publication

Purity & Quality Control

Batch: S417201 DMSO] 68 mg/mL] false] Water] 68 mg/mL] false] Ethanol] 68 mg/mL] false Purity: 99.79%

99.79

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Biological Activity

Description	Cetylpyridinium chloride(CPC) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.

In vitro
In vitro	Cetylpyridinium chloride (CPC) as active ingredient of antiseptic oral mouthrinses has a broad antimicrobial spectrum with a rapid bactericidal effect on gram-positive pathogens and a fungicide effect on yeasts in particular. Application of CPC at a concentration of 0.05% as a mouthrinse results in an immediate reduction in bacterial counts of 2.0 to 2.5 log steps (which is adequate to > 99%). This reverts to about 1 log step (= 90%) 1 h after application. The ability of CPC to inhibit plaque and thereby reduce gingivitis is assured. In comparison to chlorhexidine, CPC has a lower residual effect, and as a result a lesser effect against plaque and gingivitis. The efficacy of CPC against oropharyngeal candidiasis is assured. CPC mouthrinses can significantly reduce infectious aerosols in dental practice, thereby protecting both staff and the patient. The balance of intra-oral bacterial flora is not disturbed even in the case of relatively long-term use of CPC (up to six weeks). ^[1]

In Vivo
In vivo	Cetylpyridinium chloride increases the risk of severe allergic reactions, such as swelling of the mouth, face, lips or tongue, labored breathing, rashes, and hives. Ingesting high concentrations of cetylpyridinium chloride can lead to lung damage. Cetylpyridinium chloride is toxic if swallowed or inhaled. ^[2]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06044922	Not yet recruiting	Cardiac Arrest	CMC Ambroise Paré	February 1 2024	--
NCT04316611	Not yet recruiting	Out-of-hospital Cardiac Arrest (OHCA)	Assistance Publique - Hôpitaux de Paris\|URC-CIC Paris Descartes Necker Cochin	December 2023	Phase 2
NCT05321459	Recruiting	Coma\|Heart Arrest\|Cardiopulmonary Resuscitation	Assistance Publique - Hôpitaux de Paris\|Ecole Normale Supérieure de Paris	November 15 2023	--
NCT05969028	Not yet recruiting	Out-Of-Hospital Cardiac Arrest	University of Washington	October 2023	Not Applicable
NCT06048796	Not yet recruiting	Hypoxia-Ischemia Brain\|Heart Arrest	Medisch Spectrum Twente\|Rijnstate Hospital\|University of Twente	October 2023	Not Applicable
NCT05956431	Not yet recruiting	Heart Arrest	Peking University Third Hospital\|Qilu Hospital of Shandong University	August 1 2023	Phase 4

References

Chemical lnformation & Solubility

Molecular Weight	339.99	Formula	C₂₁H₃₈N.Cl
CAS No.	123-03-5	SDF	Download Cetylpyridinium Chloride SDF
Smiles	CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.[Cl-]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 68 mg/mL ( (200.0 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 68 mg/mL

Ethanol : 68 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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