Home Neuronal Signaling Dopamine Receptor antagonist - 5-HT Receptor antagonist - Sodium Channel inhibitor - Potassium Channel inhibitor Chlorpromazine For research use only.

Chlorpromazine

Synonyms: CPZ

Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.

Chlorpromazine Chemical Structure

Chlorpromazine Chemical Structure

CAS: 50-53-3

Selleck's Chlorpromazine has been cited by 31 publications

Purity & Quality Control

Batch: Purity: 99.12%
99.12

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Biological Activity

Description Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.
In vitro
In vitro

Chlorpromazine exerts a mild decrease in sEV uptake in only one MM cell line, indicating that the uptake of BMSC-derived sEVs by suspension MM cells may not rely on chlorpromazine-targeted receptors.[1]
Cell Research Cell lines MM1S cells, RPMI 8226, U266, H929 cells
Concentrations 5, 10, 20 μM
Incubation Time 30 min for MM1S cells, 4.5 h for RPMI 8226, U266, H929 cells
Method

MM1S cells pre-treated with heparin, cytochalasin D (Cyto D), dynasore, genistein, or chlorpromazine (CPZ) at the indicated concentrations for 30 min are cultured with 50 μg/mL DID-labeled BMSC-derived sEVs for another 4 h. The mean fluorescence intensity of DID in these cells is determined using flow cytometry. RPMI 8226, U266, or H929 cells are treated with heparin, Cyto D, dynasore, genistein, or CPZ at the indicated concentration for 4.5 h in the absence of sEVs and their cell viability is measured.
In Vivo
In vivo

Chlorpromazine suppresses the growth of endometrial cancer (EC) tumors in vivo at a low dose with no signs of toxicity.[2]
Animal Research Animal Models female BALB/c nude mice
Dosages 3 or 12 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05206747 Recruiting Mania|Sleep|Bipolar Disorder Ottawa Hospital Research Institute September 7 2022 Not Applicable
NCT03548714 Completed Alcohol Dependence|Alcohol Interaction Pop Test Oncology LLC|Pharmacotherapies for Alcohol and Substance Use Disorders Alliance|Congressionally Directed Medical Research Programs|Michael E. DeBakey VA Medical Center|Baylor College of Medicine|University of California San Diego September 1 2018 Phase 1
NCT02943213 Completed Anti-Psychotic|Management of Manifestations of Psychotic Disorders|Treatment of Schizophrenia|Control Nausea and Vomiting|Relief of Restlessness and Apprehension Before Surgery|Acute Intermittent Porphyria|Adjunct in the Treatment of Tetanus|Control Manifestations of the Manic Type of Mani-depressive Illness|Relief of Intractable Hiccups Cycle Pharmaceuticals Ltd.|Parexel November 2016 Phase 1

Chemical lnformation & Solubility

Molecular Weight 318.86 Formula

C17H19ClN2S
CAS No. 50-53-3 SDF --
Smiles CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 64 mg/mL ( (200.71 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 64 mg/mL

Water : Insoluble


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