Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Cholesterol For research use only.

Cholesterol

Synonyms: Cholesterin

Cholesterol(Cholesterin) is the principal sterol of all higher animals required to build and maintain membranes.

Cholesterol Chemical Structure

Cholesterol Chemical Structure

CAS: 57-88-5

Selleck's Cholesterol has been cited by 9 publications

Purity & Quality Control

Batch: S415401 Ethanol] 6.25 mg/mL] false] DMSO] 0.03 mg/mL] false] Water] Insoluble] false Purity: 99.6%
99.6

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Biological Activity

Description Cholesterol(Cholesterin) is the principal sterol of all higher animals required to build and maintain membranes.
In vitro
In vitro

Cholesterol serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. It modulates membrane fluidity over the range of physiological temperatures. The hydroxyl group on cholesterol interacts with the polar head groups of the membrane phospholipids and sphingolipids, while the bulky steroid and the hydrocarbon chain are embedded in the membrane, alongside the nonpolar fatty-acid chain of the other lipids. Through the interaction with the phospholipid fatty-acid chains, cholesterol increases membrane packing, which reduces membrane fluidity. The structure of the tetracyclic ring of cholesterol contributes to the decreased fluidity of the cell membrane as the molecule is in a trans conformation making all but the side chain of cholesterol rigid and planar. In this structural role, cholesterol reduces the permeability of the plasma membrane to neutral solutes, protons, and sodium ions.
In Vivo
In vivo

Cholesterol is recycled. The liver excretes it in a non-esterified form (via bile) into the digestive tract. Typically about 50% of the excreted cholesterol is reabsorbed by the small bowel back into the bloodstream.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01037387 Recruiting Chronic Obstructive Pulmonary Disease|Hypercapnic Hospital Universitario La Paz December 2025 Phase 4
NCT05867433 Recruiting Cardiovascular Diseases|Nutrition|Physical Activity Texas A&M University|National Institute on Minority Health and Health Disparities (NIMHD) August 2024 Not Applicable
NCT05561543 Not yet recruiting Hypertension|Cardiometabolic Syndrome University of Central Lancashire|University of Hertfordshire July 1 2024 Not Applicable
NCT06049420 Not yet recruiting Obesity|Hyperlipidemias|Polycystic Ovary Syndrome|Hypertension|Coronary Heart Disease|Heart Failure|Depression Anxiety|Type II Diabetes|Metabolic Syndrome West Virginia School of Osteopathic Medicine April 2024 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 386.65 Formula

C27H46O
CAS No. 57-88-5 SDF Download Cholesterol SDF
Smiles CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 6.25 mg/mL

DMSO : 0.03 mg/mL ( (0.07 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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