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Choline Chloride

Name: Choline Chloride
Brand: Selleck Chemicals
SKU: S4171
Rating: 5 (1 reviews)

Synonyms: Hepacholine

Catalog No.S4171 Purity: 100.0%

Choline chloride(Hepacholine) is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Choline Chloride Chemical Structure

CAS: 67-48-1

Selleck's Choline Chloride has been cited by 1 publication

Purity & Quality Control

Batch: S417101 DMSO] 28 mg/mL] false] Water] 28 mg/mL] false] Ethanol] 28 mg/mL] false Purity: 100.0%

100.0

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Biological Activity

Description	Choline chloride(Hepacholine) is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

In vitro
In vitro	Choline is a major part of the polar head group of phosphatidylcholine and a major part of another membrane phospholipid, sphingomyelin, which are very important for maintenance of cell structure and function. Choline deficiency in cell culture causes apoptosis or programmed cell death. Betaine or trimethylglycine is derived from choline via an oxidation reaction. Acetylcholine is one of the major neurotransmitters and requires choline for its synthesis. Adequate acetylcholine levels in the brain are believed to be protective against certain types of dementia, including Alzheimer's disease. Choline is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. Choline deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth.

In Vivo
In vivo	Choline chloride is of very low acute oral toxicity. The oral LD50 in rats is determined to be between 3150 and 5000 mg/kg bw. Clinical symptoms after application are restlessness, increased frequency of respiration, hypoactivity, convulsions, ruffled coat, staggered gait and dyspnoea. Some animals have diarrhoea and at necropsy in the high dose groups in one study 3 out of 10 rats have inflamed lungs.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06120400	Not yet recruiting	Cardiovascular Diseases	Penn State University\|American Egg Board	March 2024	Phase 3
NCT04158024	Not yet recruiting	Congenital Heart Disease in Children\|Neurologic Complication	Stanford University	January 2024	Not Applicable
NCT06029894	Recruiting	Mild Cognitive Impairment\|Alzheimer Disease	Emory University\|National Institute on Aging (NIA)	December 16 2023	Not Applicable

Chemical lnformation & Solubility

Molecular Weight	139.62	Formula	C₅H₁₄NO.Cl
CAS No.	67-48-1	SDF	Download Choline Chloride SDF
Smiles	C[N+](C)(C)CCO.[Cl-]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 28 mg/mL ( (200.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 28 mg/mL

Ethanol : 28 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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