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Ciclesonide

Name: Ciclesonide
Brand: Selleck Chemicals
SKU: S4646
Rating: 5 (5 reviews)

Synonyms: Alvesco, Omnaris, RPR251526, Zetonna

Catalog No.S4646 Purity: 99.93%

Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.

Ciclesonide Chemical Structure

CAS: 126544-47-6

Selleck's Ciclesonide has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.93%

99.93

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Biological Activity

Description	Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.

In vitro
In vitro	Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC^[2].
Cell Research	Cell lines	Human alveolar type II epithelial cells (A549).
	Concentrations	0.02 μM
	Incubation Time	1 h
	Method	Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01147224	Completed	Asthma\|Allergy	AstraZeneca	March 2010	--
NCT00793858	Withdrawn	Allergic Rhinitis	University of Chicago\|Sumitomo Pharma America Inc.	February 2009	Phase 4
NCT00826969	Completed	Asthma	AstraZeneca	September 2008	Phase 4
NCT00458835	Completed	Allergic Rhinitis	Covis Pharma S.à.r.l.	April 2007	Phase 4
NCT00367263	Completed	Asthma	Allergy & Asthma Medical Group & Research Center	October 2006	Not Applicable

References

Chemical lnformation & Solubility

Molecular Weight	540.69	Formula	C₃₂H₄₄O₇
CAS No.	126544-47-6	SDF	Download Ciclesonide SDF
Smiles	CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (184.94 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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