Home Microbiology Anti-infection chemical Clorsulon For research use only.

Clorsulon

Synonyms: MK-401,L631529

Clorsulon (MK-401,L631529) is used in the treatment of Fasciola hepatica infections in calves and sheep.

Clorsulon Chemical Structure

Clorsulon Chemical Structure

CAS: 60200-06-8

Selleck's Clorsulon has been cited by 8 publications

Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Clorsulon (MK-401,L631529) is used in the treatment of Fasciola hepatica infections in calves and sheep.
In vitro
In vitro

Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1]
In Vivo
In vivo

Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. [1] Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation. [3]
Animal Research Animal Models Rat
Dosages 12.5 mg/kg
Administration Orally

Chemical lnformation & Solubility

Molecular Weight 380.66 Formula

C8H8Cl3N3O4S2
CAS No. 60200-06-8 SDF Download Clorsulon SDF
Smiles C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 76 mg/mL ( (199.65 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 7 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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