Home Neuronal Signaling Histamine Receptor antagonist Cyclizine 2HCl For research use only.

Cyclizine 2HCl

Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.

Cyclizine 2HCl Chemical Structure

Cyclizine 2HCl Chemical Structure

CAS: 5897-18-7

Purity & Quality Control

Batch: S413901 Water] 68 mg/mL] false] DMSO] 7 mg/mL] false] Ethanol] Insoluble] false Purity: 99.48%
99.48

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Biological Activity

Description Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.
Targets
Histamine H1 receptor [1]
In vitro
In vitro Cyclizine is a histamine H1 receptor antagonist of the piperazine class. It possesses anticholinergic and antiemetic properties. The mechanism by which cyclizine exerts its antiemetic and antivertigo effects has not been fully elucidated. Cyclizine increases lower oesophageal sphincter tone and reduces the sensitivity of the labyrinthine apparatus. It may inhibit the part of the midbrain known collectively as the emetic centre. [1]
In Vivo
In vivo Cyclizine is metabolised to its N-demethylated derivative, norcyclizine, which has little antihistaminic (H1) activity compared to Cyclizine. Following oral administration effects develop within 30 minutes, are maximal within 1-2 hours and last, for cyclizine, for 4-6 hours. In healthy adult volunteers the administration of a single oral dose of 50 mg cyclizine resulted in a peak plasma concentration of approximately 70 ng/mL occurring at about two hours after drug administration. The plasma elimination half-life is approximately 20 hours. [1]

Chemical lnformation & Solubility

Molecular Weight 339.3 Formula

C18H22N2.2HCl
CAS No. 5897-18-7 SDF Download Cyclizine 2HCl SDF
Smiles CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 68 mg/mL

DMSO : 7 mg/mL ( (20.63 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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