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Cysteamine HCl

Name: Cysteamine HCl
Brand: Selleck Chemicals
SKU: S4206
Rating: 5 (2 reviews)

Synonyms: Mercaptamine

Catalog No.S4206 Purity: 100.0%

Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.

Cysteamine HCl Chemical Structure

CAS: 156-57-0

Selleck's Cysteamine HCl has been cited by 2 publications

Purity & Quality Control

Batch: S420601 DMSO] 23 mg/mL] false] Water] 23 mg/mL] false] Ethanol] 23 mg/mL] false Purity: 100.0%

100.0

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Biological Activity

Description	Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.

In vitro
In vitro	Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of ^OH and HOCl; it also reacts with H₂O₂. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death. ^[1] Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes. ^[2]

In Vivo
In vivo	Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. ^[1]

References

Chemical lnformation & Solubility

Molecular Weight	113.61	Formula	C₂H₇NS.HCl
CAS No.	156-57-0	SDF	Download Cysteamine HCl SDF
Smiles	C(CS)N.Cl
Storage (From the date of receipt)	3 years -20°C powder (seal)	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder (seal)		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 23 mg/mL ( (202.44 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 23 mg/mL

Ethanol : 23 mg/mL

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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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