Home Neuronal Signaling NMDAR agonist D-Alanine For research use only.

D-Alanine

Synonyms: Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286

D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.

D-Alanine Chemical Structure

D-Alanine Chemical Structure

CAS: 338-69-2

Purity & Quality Control

Batch: S320301 Water] 18 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.87%
99.87

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Biological Activity

Description D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.
Targets
NMDA receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05105958 Not yet recruiting Amyotrophic Lateral Sclerosis University Hospital Geneva|University of Lausanne Hospitals|University of Zurich|University of Bern|Cantonal Hospital of St. Gallen December 1 2025 Phase 2
NCT05847179 Not yet recruiting Werner Syndrome PRG Science & Technology Co. Ltd. January 1 2025 Phase 2
NCT06154096 Not yet recruiting Steatosis of Liver Imperial College London March 2024 --
NCT03468556 Not yet recruiting NASH - Nonalcoholic Steatohepatitis Sinew Pharma Inc. March 1 2024 Phase 2
NCT04530058 Not yet recruiting Burns Hamilton Health Sciences Corporation March 2024 Phase 2
NCT06039644 Not yet recruiting Breast Cancer GenMont Biotech Incorporation|Mackay Memorial Hospital March 1 2024 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 89.09 Formula

C3H7NO2
CAS No. 338-69-2 SDF --
Smiles CC(C(=O)O)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 18 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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