Home Neuronal Signaling NMDAR modulator D-Aspartic acid For research use only.

D-Aspartic acid

Synonyms: Asp, Aminosuccinic acid, asparagic acid, asparaginic acid

D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).

D-Aspartic acid Chemical Structure

D-Aspartic acid Chemical Structure

CAS: 1783-96-6

Purity & Quality Control

Batch: S512901 5%TFA] 6.02 mg/mL] false] DMSO] 0.01 mg/mL] false] Water] Insoluble] false Purity: 98%
98

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Biological Activity

Description D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).
In vitro
In vitro D-aspartate (D-Asp) is an endogenous amino acid present in vertebrate tissues, with particularly high levels in the testis. In vitro studies have demonstrated that D-Asp up-regulates testosterone production in Leydig cells by enhancing expression of the steroidogenic acute regulatory protein. Besides testosterone release, D-Asp induced E2 synthesis through aromatase activation[1].
Cell Research Cell lines GC-1 cells
Concentrations 200 μM
Incubation Time 30 min, 2 h, 4 h
Method

Cultures were carried on in the presence of D-Asp (200 μM; diluted in distilled H2O) in different time exposure of the amino acid (30 min, 2 h, 4 h). Control cultures were treated with vehicle alone. At the end of the incubation period, cells were rinsed in PBS, harvested by trypsinization, collected by centrifugation at 1,000g for 10 min and immediately frozen at  80°C for biochemical analyses.
In Vivo
In vivo In vivo studies indicate that D-Asp indirectly stimulates spermatogenesis through the hypothalamic-pituitary-gonadal axis. The oral and/or intraperitoneal D-Asp administration to adult rats induced an increase of serum progesterone and LH as well as an increase of testis/serum testosterone levels, whereas 17β-estradiol (E2) levels did no change[1]. D-aspartic acid has significant analgesic activity[2].
Animal Research Animal Models Inbred albino BALB/C mice
Dosages 55, 115, and 230 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05847179 Not yet recruiting Werner Syndrome PRG Science & Technology Co. Ltd. January 1 2025 Phase 2
NCT05777512 Recruiting Bronchopulmonary Dysplasia Boston Children''s Hospital|Beth Israel Deaconess Medical Center October 2024 Not Applicable
NCT05638568 Not yet recruiting Surfactant Deficiency Syndrome Neonatal|Respiratory Distress Syndrome Newborn|Bronchopulmonary Dysplasia Rigshospitalet Denmark|Odense University Hospital|Aalborg University Hospital|Aarhus University Hospital|Holbaek Sygehus July 1 2024 Not Applicable
NCT03468556 Not yet recruiting NASH - Nonalcoholic Steatohepatitis Sinew Pharma Inc. March 1 2024 Phase 2
NCT06039644 Not yet recruiting Breast Cancer GenMont Biotech Incorporation|Mackay Memorial Hospital March 1 2024 Not Applicable
NCT05951231 Not yet recruiting Liver Transplant; Complications|Transplant; Failure Liver|Transplant Dysfunction|Transplant; Complication Rejection|Transplant|Liver Metastases|Liver Cancer Oslo University Hospital|South-Eastern Norway Regional Health Authority February 2024 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 133.10 Formula

C4H7NO4
CAS No. 1783-96-6 SDF Download D-Aspartic acid SDF
Smiles C(C(C(=O)O)N)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

5%TFA : 6.02 mg/mL

DMSO : 0.01 mg/mL ( (0.07 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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