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D-Phenylalanine

D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain.

D-Phenylalanine Chemical Structure

D-Phenylalanine Chemical Structure

CAS: 673-06-3

Purity & Quality Control

Batch: S415301 Water] 1 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.9%
99.9

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Biological Activity

Description D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain.
Targets
carboxypeptidase A [1] endorphinase [1] enkephalinase [1]
In vitro
In vitro The binding of D-Phenylalanine to carboxypeptidase A confers anion sensitivity upon the function of the enzyme by breaking the hydrogen bond between the active site base, Glu-270, and the zinc-bound water molecule. [1]
In Vivo
In vivo D-Phenylalanine (500 mg/kg p.o.) produces a small increase in aversive threshold which is not statistically significant and not naloxone reversible. Acetylsalicylic acid (200 mg/kg p.o.) but not zomepirac sodium (200 mg/kg p.o.) in combination with D-phenylalanine (500 mg/kg) produces a small statistically significant increase in aversive threshold. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05514470 Not yet recruiting Interstitial Lung and Liver Disease|Infantile Liver Failure Syndrome 1|Neurologic Endocrine and Pancreatic Disease Multisystem Infantile-Onset 2|Rajab Interstitial Lung Disease With Brain Calcifications 2 Assistance Publique - Hôpitaux de Paris April 2023 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 165.19 Formula

C9H11NO2
CAS No. 673-06-3 SDF Download D-Phenylalanine SDF
Smiles C1=CC=C(C=C1)CC(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 1 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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