Home Microbiology Influenza Virus chemical D-Pinitol For research use only.

D-Pinitol

Synonyms: Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol

D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.

D-Pinitol Chemical Structure

D-Pinitol Chemical Structure

CAS: 10284-63-6

Purity & Quality Control

Batch: S387001 DMSO] 38 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Biological Activity

Description D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.
In vitro
In vitro D-pinitol reduces the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Treatment of prostate cancer cells with D-pinitol reduces mRNA and cell surface expression of αvβ3 integrin. In addition, D-pinitol exerts its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-κB activation[1].
Cell Research Cell lines Human prostate cancer cell lines (PC3 and DU145)
Concentrations 0, 1, 3, 10 and 30 μM
Incubation Time 24 h
Method For invasion assay, filters are precoated with 30 μL Matrigel basement membrane matrix for 30 min. The following procedures are the same for both migration and invasion assays. After the treatment with D-pinitol (0, 1, 3, 10 and 30 μM) for 24 h, cells are harvested and seeded to Transwell at 1 × 104 cells/well in serum-free medium and then incubated for 24 h at 37 °C in 5% CO2. Cells are then fixed in 3.7% formaldehyde for 5 min and stained with 0.05% crystal violet in PBS for 15 min. Cells on the upper side of the filters are removed with cotton-tipped swabs, and the filters are washed with PBS. Cells on the underside of the filters are examined and counted under a microscope.
In Vivo
In vivo D-pinitol exerts an acute and chronically-sustained antihyperglycaemic effect in the murine STZ-induced model of hypoinsulinaemic diabetes. The mechanism of action of D-pinitol does not augment the effect of insulin but might involve an interaction with part of a cellular signalling pathway that links insulin with glucose transport[2].
Animal Research Animal Models Obese-diabetic ob/ob mice
Dosages up to 100 mg/kg
Administration p.o./i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01754792 Completed Type 2 Diabetes|Impaired Glucose Tolerance|Healthy University of Valencia January 2012 Not Applicable
NCT01738763 Completed Healthy|Insulin Sensitivity University of Valencia July 2011 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 194.18 Formula

C7H14O6
CAS No. 10284-63-6 SDF --
Smiles COC1C(C(C(C(C1O)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (195.69 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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