Home Neuronal Signaling AChR agonist Decamethonium Bromide For research use only.

Decamethonium Bromide

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

Decamethonium Bromide Chemical Structure

Decamethonium Bromide Chemical Structure

CAS: 541-22-0

Purity & Quality Control

Batch: S407201 Water] 84 mg/mL] false] DMSO] 34 mg/mL] false] Ethanol] 25 mg/mL] false Purity: 100.00%
100.00

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Biological Activity

Description Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.
Targets
nAChR [1]
In vitro
In vitro Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release. [1]

Chemical lnformation & Solubility

Molecular Weight 418.29 Formula

C16H38N2.2Br
CAS No. 541-22-0 SDF Download Decamethonium Bromide SDF
Smiles C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]
Storage (From the date of receipt)

In vitro
Batch:

Water : 84 mg/mL

DMSO : 34 mg/mL ( (81.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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