Home Immunology & Inflammation SPHK activator Defensamide (MHP) For research use only.

Defensamide (MHP)

Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.

Defensamide (MHP) Chemical Structure

Defensamide (MHP) Chemical Structure

CAS: 1104874-94-3

Purity & Quality Control

Batch: S651201 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] Insoluble] false Purity: 99.78%
99.78

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Biological Activity

Description Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
Targets
SPHK1 [1]
In vitro
In vitro

Treatment with MHP directly activates SPHK1 and increases cellular S1P content in normal cultured human keratinocytes. MHP also stimulates CAMP production and enhances epidermal antimicrobial defense via the recently identified S1P-dependent mechanism[1]. Defensamide (MHP) treatment also activates NF-κB which is assessed by nuclear translocation of NF-κB[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04364230 Active not recruiting Melanoma|Ocular Melanoma|Uveal Melanoma Craig L Slingluff Jr|Celldex Therapeutics|University of Virginia September 28 2020 Phase 1|Phase 2
NCT02515227 Completed Melanoma Craig L Slingluff Jr|National Cancer Institute (NCI)|University of Virginia October 6 2016 Phase 1|Phase 2

Chemical lnformation & Solubility

Molecular Weight 293.36 Formula
C16H23NO4
 
CAS No. 1104874-94-3 SDF --
Smiles CCCCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (340.87 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


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In vivo
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