Home Immunology & Inflammation Peroxidases inhibitor - Interleukins inhibitor - TNF-alpha inhibitor - NF-κB inhibitor - AMPK activator Demethyleneberberine For research use only.

Demethyleneberberine

Synonyms: DMB

Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.

Demethyleneberberine Chemical Structure

Demethyleneberberine Chemical Structure

CAS: 25459-91-0

Purity & Quality Control

Batch: S329901 DMSO] 3 mg/mL] false] ] ] false] ] ] false Purity: 99.01%
99.01

Related compound libraries

Choose Selective Peroxidases Inhibitors

Biological Activity

Description Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.
Targets
NF-κB [1] MPO [1] IL-6 [1] TNF-α [1] IL-1β [1] Click to View More Targets
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04785326 Completed Moderate to Severe Chronic Plaque Psoriasis Dong-A ST Co. Ltd.|Meiji Seika Pharma Co. Ltd. April 28 2021 Phase 3

Chemical lnformation & Solubility

Molecular Weight 324.35 Formula

C19H18NO4
CAS No. 25459-91-0 SDF --
Smiles COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(O)C=C4CC3)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 3 mg/mL ( (9.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Demethyleneberberine | Demethyleneberberine supplier | purchase Demethyleneberberine | Demethyleneberberine cost | Demethyleneberberine manufacturer | order Demethyleneberberine | Demethyleneberberine distributor