Home Proteases Tyrosinase inhibitor Deoxyarbutin For research use only.

Deoxyarbutin

Synonyms: D-arbutin,D-Arb

DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.

Deoxyarbutin Chemical Structure

Deoxyarbutin Chemical Structure

CAS: 53936-56-4

Purity & Quality Control

Batch: S413201 DMSO] 39 mg/mL] false] Ethanol] 39 mg/mL] false] Water] Insoluble] false Purity: 99.32%
99.32

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Biological Activity

Description DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.
Features More effective than hydroquinone in inhibiting mushroom tyrosinase.
Targets
tyrosinase [1]
50 nM
In vitro
In vitro

DeoxyArbutin demonstrates effective inhibition of mushroom tyrosinase in vitro with a Ki that is 10-fold lower that hydroquinone (HQ) and 350-fold lower than arbutin. [1] DeoxyArbutin exhibits toxicity in darkly (higher tyrosinase activity) and lightly (lower tyrosinase activity) pigmented melanocytes with IC50 of 57.5 μM and 104.7 μM. DeoxyArbutin (100 μM) dose-dependently inhibits tyrosine hydroxylase activity in lysate from untreated, darkly pigmented melanocytes. DeoxyArbutin (100 μM) inhibits tyrosine hydroxylase activity of mushroom tyrosinase in a dose-dependent manner. DeoxyArbutin inhibits tyrosine hydroxylase activity of mushroom tyrosinase with IC50 of 17.5 μM and Ki of 21.6 μM. [2] Water increases the decomposition of DeoxyArbutin in the formulations and the polyol-in-silicone, oil-based, anhydrous emulsion system provides a relatively stable surrounding for the DeoxyArbutin that delays its degradation at 25 ℃ and 45 ℃. [3] DeoxyArbutin inhibits melanin synthesis in intact melanocytes in a dose-dependent manner. DeoxyArbutin exhibits dose-dependent reductions in melanocyte cell number, primarily due to inhibition of proliferation rather than initiation of apoptosis. DeoxyArbutin increases minimal amounts of reactive oxygen species (ROS) with subsequently induced expression of the endogenous antioxidant catalase in treated melanocytes.[4]
In Vivo
In vivo

DeoxyArbutin (3%) demonstrates rapid and sustained skin lightening that is completely reversible within 8 weeks after halt in topical application in a hairless, pigmented guinea pig model. [1]

Chemical lnformation & Solubility

Molecular Weight 194.23 Formula

C11H14O3
CAS No. 53936-56-4 SDF Download Deoxyarbutin SDF
Smiles C1CCOC(C1)OC2=CC=C(C=C2)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (200.79 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 39 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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