Home Neuronal Signaling Adrenergic Receptor chemical Deoxycorticosterone acetate For research use only.

Deoxycorticosterone acetate

Synonyms: 11-Deoxycorticosterone acetate, DOC acetate, Cortexone acetate

Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Deoxycorticosterone acetate Chemical Structure

Deoxycorticosterone acetate Chemical Structure

CAS: 56-47-3

Selleck's Deoxycorticosterone acetate has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.94%
99.94

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Biological Activity

Description Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.
In Vivo
In vivo Deoxycorticosterone acetate (DOCA) is an agent commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05633953 Active not recruiting Cushing''s Syndrome RECORDATI GROUP January 16 2023 --
NCT01331239 Completed Cushings Disease|Cushing Disease Novartis Pharmaceuticals|Novartis March 23 2011 Phase 2
NCT01186484 Completed Prostatic Neoplasms Janssen Pharmaceutical K.K. June 1 2010 Phase 1

Chemical lnformation & Solubility

Molecular Weight 372.5 Formula

C23H32O4
CAS No. 56-47-3 SDF Download Deoxycorticosterone acetate SDF
Smiles CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 11 mg/mL ( (29.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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