Home TGF-beta/Smad PKC inhibitor Dequalinium Chloride For research use only.

Dequalinium Chloride

Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.

Dequalinium Chloride Chemical Structure

Dequalinium Chloride Chemical Structure

CAS: 522-51-0

Selleck's Dequalinium Chloride has been cited by 3 publications

Purity & Quality Control

Batch: S406601 4-Methylpyridine] 3 mg/mL] true] DMSO] 0.025 mg/mL] false] Water] Insoluble] false Purity: 99.13%
99.13

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Biological Activity

Description Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.
Targets
PKC [1]
7 μM-18 μM
In vitro
In vitro Dequalinium chloride (DECA) is a cationic, lipophilic compound with structure similar to the dye rhodamine 123. DECA is selectively accumulated and retained within the mitochondria of carcinoma cells where it acts as a mitochondrial poison by blocking mitochondrial enzymes which can then disrupt cellular energy production, eventually resulting in cell death. Dequalinium Chloride is a blocker of ganglionic transmission (EC50 = 2 μM). [1] Dequalinium is a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle. Dequalinium blocks angiotensin II-evoked K+ loss with an IC50 of 1.5 μM and also inhibited125I - monoiodoapamin binding with Ki of 1.1 μM. [2] Dequalinium produces a rapid and reversible inhibition of the slow apamin-sensitive component of the afterhyperpolarization (AHP) which follows a single action potential in cultured rat sympathetic neurones. [3] Dequalinium Chloride (DECA) is a dicationic lipophilic PKC inhibitor. When exposed to UV light, DECA covalently binds to and irreversibly inhibits PKCα and PKCβ. [4]
In Vivo
In vivo In mice bearing bladder MB49 tumors, Dequalinium chloride (2 mg/kg/d, i.p.) displays anticarcinoma activity with T/C of 210%. [5]
Animal Research Animal Models Mice bearing bladder MB49 tumors
Dosages 2 mg/kg/d
Administration i.p.

Chemical lnformation & Solubility

Molecular Weight 527.57 Formula

C30H40N4.2Cl
CAS No. 522-51-0 SDF Download Dequalinium Chloride SDF
Smiles CC1=[N+](C2=CC=CC=C2C(=C1)N)CCCCCCCCCC[N+]3=C(C=C(C4=CC=CC=C43)N)C.[Cl-].[Cl-]
Storage (From the date of receipt)

In vitro
Batch:

4-Methylpyridine : 3 mg/mL

DMSO : 0.025 mg/mL ( (0.04 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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