Home Metabolism Fatty Acid Synthase inhibitor - Carbohydrate Metabolism inhibitor - Apoptosis related activator Desoxyrhaponticin For research use only.

Desoxyrhaponticin

Synonyms: DC, DES

Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.

Desoxyrhaponticin Chemical Structure

Desoxyrhaponticin Chemical Structure

CAS: 30197-14-9

Selleck's Desoxyrhaponticin has been cited by 1 publication

Purity & Quality Control

Batch: S330001 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.88%
99.88

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Biological Activity

Description Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Targets
FAS/FASN [1] glucose [2]
(in rat everted gut sleeves)		 glucose [2]
(in rabbit intestinal membrane vesicles)
30.9 μM 148.3 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04231058 Suspended Dyspnea Azienda USL Toscana Nord Ovest|Auxilium Vitae Volterra May 1 2024 Not Applicable
NCT06127407 Not yet recruiting Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation Untreated or Previously Treated With 1 Systemic Treatment Regimen Servier Bio-Innovation LLC|Institut de Recherches Internationales Servier|Servier April 1 2024 Phase 3
NCT06193382 Not yet recruiting Traumatic Brain Injury|Disruptive Behavior University of Miami March 1 2024 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 404.41 Formula

C21H24O8
CAS No. 30197-14-9 SDF --
Smiles COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O)OC3OC(CO)C(O)C(O)C3O
Storage (From the date of receipt) 3 years -20°C powder

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DMSO : 100 mg/mL ( (247.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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