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Dexamethasone Acetate

Name: Dexamethasone Acetate
Brand: Selleck Chemicals
SKU: S3124
Rating: 5 (34 reviews)

Synonyms: NSC 39471,Dexamethasone 21-acetate

Catalog No.S3124 Purity: 99.86%

Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Dexamethasone Acetate Chemical Structure

CAS: 1177-87-3

Selleck's Dexamethasone Acetate has been cited by 34 publications

Purity & Quality Control

Batch: Purity: 99.86%

99.86

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Biological Activity

Description

Targets

interleukin receptor ^[1]

In vitro
In vitro	Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. ^[1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. ^[2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. ^[3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. ^[5]
Experimental Result Images	Methods	Biomarkers	Images	PMID
	Western blot	p-AKT / AKT GRP78 / GRP94 / pIREα / IREα / peIF2α / eIF2α CHOP BCRP / P-gp / Mrp2		29436611
	Immunofluorescence	GRP78		24691439
	Growth inhibition assay	Cell viability		22719835

In Vivo
In vivo	Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. ^[4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. ^[5]
Animal Research	Animal Models	Sprague-Dawley rats
	Dosages	100 μg/kg
	Administration	Intraperitoneal injection

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06118710	Not yet recruiting	Cancer	Erasmus Medical Center	January 1 2024	Phase 4
NCT05759481	Not yet recruiting	Post-operative Nausea and Vomiting	Milton S. Hershey Medical Center	January 2024	Phase 2
NCT06133712	Recruiting	Carpal Tunnel\|Dexmedetomidine\|Ozone\|Dexamethasone	Tanta University	November 1 2023	Not Applicable
NCT05994183	Withdrawn	Bronchiolitis	IDeA States Pediatric Clinical Trials Network\|National Institutes of Health (NIH)\|University of Nebraska	October 9 2023	Early Phase 1

References

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Chemical lnformation & Solubility

Molecular Weight	434.5	Formula	C₂₄H₃₁FO₆
CAS No.	1177-87-3	SDF	Download Dexamethasone Acetate SDF
Smiles	CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 87 mg/mL ( (200.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

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In vivo
Batch:

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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