Home Metabolism PPAR antagonist DG172 dihydrochloride For research use only.

DG172 dihydrochloride

DG-172 dihydrochloride is a novel PPARβ/δ-selective antagonist with the IC50 of 27 nM.

DG172 dihydrochloride Chemical Structure

DG172 dihydrochloride Chemical Structure

CAS: 1361504-77-9

Selleck's DG172 dihydrochloride has been cited by 1 publication

Purity & Quality Control

Batch: S053101 DMSO] 91 mg/mL] false] Water] 44 mg/mL] false] Ethanol] 23 mg/mL] false Purity: 99.17%
99.17

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Biological Activity

Description DG-172 dihydrochloride is a novel PPARβ/δ-selective antagonist with the IC50 of 27 nM.
Targets
PPARβ/δ [1]
(in a competitive TR-FRET assay)
27 nM
In vitro
In vitro

DG-172 dihydrochloride selectively inhibits the agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts. [1]
Cell Research Cell lines C2C12 mouse myoblasts
Concentrations 0.01, 0.1, 1, 10, 100, 1000, 10000, 100000 nM
Incubation Time 24 h
Method

C2C12 mouse myoblasts are treated for 24 h with DG-172 at the indicated concentration, and RNA is analyzed by RT-qPCR.

Chemical lnformation & Solubility

Molecular Weight 455.22 Formula

C20H20BrN3.2ClH
CAS No. 1361504-77-9 SDF --
Smiles CN1CCN(CC1)C2=CC=C(C=C2)C=C(C#N)C3=CC=CC=C3Br.Cl.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 91 mg/mL ( (199.9 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 44 mg/mL

Ethanol : 23 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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