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Dianhydrogalactitol (VAL-083)

Name: Dianhydrogalactitol (VAL-083)
Brand: Selleck Chemicals
SKU: S6984

Synonyms: Dianhydrodulcitol, Dulcitol Diepoxide

Catalog No.S6984 Purity: 98.57%

Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

Dianhydrogalactitol (VAL-083) Chemical Structure

CAS: 23261-20-3

Purity & Quality Control

Batch: S698401 DMSO] 29 mg/mL] false] Water] 29 mg/mL] false] Ethanol] 29 mg/mL] false Purity: 98.57%

98.57

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Biological Activity

Description	Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03281681	Withdrawn	Ovarian Cancer	DelMar Pharmaceuticals Inc.\|Kintara Therapeutics Inc.	March 2021	Phase 1\|Phase 2
NCT03050736	Active not recruiting	Glioma\|Glioblastoma\|Glioblastoma Multiforme\|GBM\|Brain Cancer	Kintara Therapeutics Inc.\|Sun Yat-sen University	December 17 2017	Phase 2
NCT02717962	Active not recruiting	Glioma\|Glioblastoma\|Glioblastoma Multiforme\|GBM\|Brain Cancer	Kintara Therapeutics Inc.	January 20 2017	Phase 2

References

[1] Kaiji Hu, et al. Cancer Research. AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012.

Chemical lnformation & Solubility

Molecular Weight	146.14	Formula	C₆H₁₀O₄
CAS No.	23261-20-3	SDF	--
Smiles	OC(C(O)C1CO1)C2CO2
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 29 mg/mL ( (198.43 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 29 mg/mL

Ethanol : 29 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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