Home Immunology & Inflammation Nrf2 activator DMF (Dimethyl Fumarate) For research use only.

DMF (Dimethyl Fumarate)

Synonyms: BG-12

DMF (Dimethyl Fumarate) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.

DMF (Dimethyl Fumarate) Chemical Structure

DMF (Dimethyl Fumarate) Chemical Structure

CAS: 624-49-7

Selleck's DMF (Dimethyl Fumarate) has been cited by 13 Publications

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Purity & Quality Control

Batch: Purity: 99.98%
99.98

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Biological Activity

Description DMF (Dimethyl Fumarate) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.
In vitro
In vitro

Dimethyl fumarate causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells. [1] Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling. [2] Dimethyl fumarate inhibits TNF-alpha-induced nuclear entry of NF-kappaB in rat heart endothelial cells (RHEC). [3] Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release. Dimethyl fumarate attenuates CCL2-induced monocyte chemotaxis, suggesting that Dimethyl fumarate could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators. [4]
Experimental Result Images Methods Biomarkers Images PMID
Western blot NRF2 / IRP2 / FBXL5 / FTH1 / FTL 28289076
In Vivo
In vivo

Dimethyl fumarate inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo. [3] Dimethyl fumarate oral administration is shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06182657 Recruiting Nasopharyngeal Carcinoma|Pathologic Complete Response|Tumor Microenvironment Jiangxi Provincial Cancer Hospital January 1 2024 --

Chemical lnformation & Solubility

Molecular Weight 144.13 Formula

C6H8O4
CAS No. 624-49-7 SDF Download DMF (Dimethyl Fumarate) SDF
Smiles COC(=O)C=CC(=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 29 mg/mL ( (201.2 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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