Home Hippo MAP4K inhibitor DMX-5084 For research use only.

DMX-5084

DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

DMX-5084 Chemical Structure

DMX-5084 Chemical Structure

CAS: 2306178-56-1

Selleck's DMX-5084 has been cited by 1 publication

Purity & Quality Control

Batch: S026801 DMSO] 72 mg/mL] false] Ethanol] 1.5 mg/mL] false] Water] Insoluble] false Purity: 99.69%
99.69

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Biological Activity

Description DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.
Targets
human MAP4K4 [1]
(Cell-free assay)		 human MAP4K4 [1]
(Cell-free assay)		 MINK1/MAP4K6 [1]
(Cell-free assay)		 TNIK/MAP4K7 [1]
(Cell-free assay)
8.55(pIC50) 3 nM 8.18(pIC50) 7.96(pIC50)

Chemical lnformation & Solubility

Molecular Weight 361.39 Formula

C21H19N3O3
CAS No. 2306178-56-1 SDF --
Smiles COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 72 mg/mL ( (199.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 1.5 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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