Home Metabolism PDE inhibitor Doxofylline For research use only.

Doxofylline

Synonyms: Doxophylline

Doxofylline (Doxophylline) is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.

Doxofylline Chemical Structure

Doxofylline Chemical Structure

CAS: 69975-86-6

Selleck's Doxofylline has been cited by 1 publication

Purity & Quality Control

Batch: S416401 DMSO] 53 mg/mL] false] Water] 24 mg/mL] false] Ethanol] 2 mg/mL] false Purity: 99.84%
99.84

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Biological Activity

Description Doxofylline (Doxophylline) is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.
Targets
PDE [1]
In vitro
In vitro Doxofylline has PDE inhibitor activity and can increase the level of cAMP, which could, therefore, be used for the treatment of asthma and COPD. EC50 value of Doxofylline is 15 times higher than that of aminophylline in inhibiting the adenosine-induced relaxation of tracheal smooth muscle and 10 times higher in reducing the negative inotropic effect induced by adenosine on isolated guinea-pig atria. Doxofylline could effectively decrease the open probability of the calcium-activated potassium channels as a result of both the shortening of open period and the prolongation of close time. Doxofylline has greatly decreased affinity towards adenosine A1 and A2 receptors when compared with theophylline, which may contribute to the better safety profile. Moreover, unlike theophylline, Doxofylline does not interfere with calcium influx into cells nor antagonizes the action of calcium-channel blockers. [1]
In Vivo
In vivo Doxofylline has been shown to have better efficacy with fewer side effects than theophylline. 30 mg/kg Doxofylline increases heart rate of anaesthetized cat by 13 beats/min. The effective therapeutic dose of Doxofylline has less cardio-stimulant effects than Theophylline, such that Doxofylline does not out significantly increase the cardiac frequency nor does it have arrhythmogenic effects. [2]

Chemical lnformation & Solubility

Molecular Weight 266.25 Formula

C11H14N4O4
CAS No. 69975-86-6 SDF Download Doxofylline SDF
Smiles CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3OCCO3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (199.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 24 mg/mL

Ethanol : 2 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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