Home Microbiology HIV inhibitor - COVID-19 inhibitor Ebselen For research use only.

Ebselen

Synonyms: DR 3305, SPI-1005, PZ-51, CCG-39161

Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.

Ebselen Chemical Structure

Ebselen Chemical Structure

CAS: 60940-34-3

Selleck's Ebselen has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.76%
99.76

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Biological Activity

Description Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.
Targets
HIV-1 [1]
(Cell-free assay)
46.1 nM
In vitro
In vitro

Ebselen acts on the early postentry step of the HIV-1 viral cycle prior to reverse transcription by stabilizing the incoming viral capsid.[1]
Cell Research Cell lines HeLa-CD4 cells
Concentrations 0-100µM
Incubation Time 72 h
Method

HeLa-CD4-LTR-LacZ cells are infected with NL4.3 replicative virus in the presence of increasing concentrations of ebselen for 72 h.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03013400 Completed Bipolar Disorder|Bipolar Disorder Manic University of Oxford|Stanley Medical Research Institute|Sound Pharmaceuticals Incorporated October 1 2017 Phase 2
NCT02603081 Completed Meniere''s Disease Sound Pharmaceuticals Incorporated December 2015 Phase 1|Phase 2
NCT01452607 Completed Hearing Loss|Cancer Sound Pharmaceuticals Incorporated May 2006 Phase 1
NCT00762671 Completed Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus Brigham and Women''s Hospital May 1999 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 274.18 Formula

C13H9NOSe
CAS No. 60940-34-3 SDF --
Smiles C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 55 mg/mL ( (200.59 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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